Relic of Progenitus

{T}: Target player exiles a card from their graveyard.
{1}, Exile Relic of Progenitus: Exile all graveyards. Draw a card.

Retribution of the Meek

Destroy all creatures with power 4 or greater. They can't be regenerated.

Planar Outburst

Destroy all nonland creatures.
Awaken 4—{5}{W}{W}{W} (If you cast this spell for {5}{W}{W}{W}, also put four +1/+1 counters on target land you control and it becomes a 0/0 Elemental creature with haste. It's still a land.)

False Prophet

When False Prophet dies, exile all creatures.

Serenity

At the beginning of your upkeep, destroy all artifacts and enchantments. They can't be regenerated.

Plague Boiler

At the beginning of your upkeep, put a plague counter on Plague Boiler.
{1}{B}{G}: Put a plague counter on Plague Boiler or remove a plague counter from it.
When Plague Boiler has three or more plague counters on it, sacrifice it. If you do, destroy all nonland permanents.

Armageddon

Wrath of God

Destroy all creatures. They can't be regenerated.

Boompile

{T}: Flip a coin. If you win the flip, destroy all nonland permanents.

Morningtide

Primeval Light

Destroy all enchantments target player controls.

Catastrophe

Destroy all lands or all creatures. Creatures destroyed this way can't be regenerated.

Scavenger Grounds

{T}: Add {C}.
{2}, {T}, Sacrifice a Desert: Exile all graveyards.

Cleanfall

Fortunate Few

Choose a nonland permanent you don't control, then each other player chooses a nonland permanent they don't control that hasn't been chosen this way. Destroy all other nonland permanents.

Ravnica at War

Day of Judgment

Bane of Progress

When Bane of Progress enters, destroy all artifacts and enchantments. Put a +1/+1 counter on Bane of Progress for each permanent destroyed this way.

Tsunami

Phyrexian Scriptures

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — Put a +1/+1 counter on up to one target creature. That creature becomes an artifact in addition to its other types.
II — Destroy all nonartifact creatures.
III — Exile all opponents' graveyards.

Final Judgment

Shatterstorm

Destroy all artifacts. They can't be regenerated.

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.

Kalemne's Captain

Vigilance
{5}{W}{W}: Monstrosity 3. (If this creature isn't monstrous, put three +1/+1 counters on it and it becomes monstrous.)
When Kalemne's Captain becomes monstrous, exile all artifacts and enchantments.

Citywide Bust

Destroy all creatures with toughness 4 or greater.

Angel of the Dire Hour

Flash
Flying
When Angel of the Dire Hour enters, if you cast it from your hand, exile all attacking creatures.

Ritual of Soot

Destroy all creatures with mana value 3 or less.

Kirtar's Wrath

Destroy all creatures. They can't be regenerated.
Threshold — If seven or more cards are in your graveyard, instead destroy all creatures, then create two 1/1 white Spirit creature tokens with flying. Creatures destroyed this way can't be regenerated.

Patrician's Scorn

If you've cast another white spell this turn, you may cast this spell without paying its mana cost.
Destroy all enchantments.

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Devastation

Deadly Tempest

Destroy all creatures. Each player loses life equal to the number of creatures they controlled that were destroyed this way.

Play of the Game

Assist (Another player can pay up to {6} of this spell's cost.)
Exile all nonland permanents.

Back to Nature

Purify

Elspeth Tirel

+2: You gain 1 life for each creature you control.
−2: Create three 1/1 white Soldier creature tokens.
−5: Destroy all other permanents except for lands and tokens.

Apocalypse

Exile all permanents. You discard your hand.

Reiver Demon

Flying
When Reiver Demon enters, if you cast it from your hand, destroy all nonartifact, nonblack creatures. They can't be regenerated.

Rout

You may cast Rout as though it had flash if you pay {2} more to cast it. (You may cast it any time you could cast an instant.)
Destroy all creatures. They can't be regenerated.

Crux of Fate

Choose one —
• Destroy all Dragon creatures.
• Destroy all non-Dragon creatures.

Obliterate

This spell can't be countered.
Destroy all artifacts, creatures, and lands. They can't be regenerated.

Mass Calcify

Serene Heart

Martial Coup

Create X 1/1 white Soldier creature tokens. If X is 5 or more, destroy all other creatures.

Damnation

Sentinel Totem

When Sentinel Totem enters, scry 1. (Look at the top card of your library. You may put that card on the bottom.)
{T}, Exile Sentinel Totem: Exile all graveyards.

Extinguish All Hope

Rest in Peace

When Rest in Peace enters, exile all graveyards.
If a card or token would be put into a graveyard from anywhere, exile it instead.

Hush

Destroy all enchantments.
Cycling {2} ({2}, Discard this card: Draw a card.)

Jokulhaups

Destroy all artifacts, creatures, and lands. They can't be regenerated.

Urza's Ruinous Blast

(You may cast a legendary sorcery only if you control a legendary creature or planeswalker.)
Exile all nonland permanents that aren't legendary.

Calming Verse

Destroy all enchantments you don't control. Then if you control an untapped land, destroy all enchantments you control.

Aligned Hedron Network

When Aligned Hedron Network enters, exile all creatures with power 5 or greater until Aligned Hedron Network leaves the battlefield. (Those creatures return under their owners' control.)

Perilous Vault

{5}, {T}, Exile Perilous Vault: Exile all nonland permanents.

Hour of Reckoning

Convoke (Your creatures can help cast this spell. Each creature you tap while casting this spell pays for {1} or one mana of that creature's color.)
Destroy all nontoken creatures.

Ruination

Harsh Mercy

Each player chooses a creature type. Destroy all creatures that aren't of a type chosen this way. They can't be regenerated.

Sublime Exhalation

Undaunted (This spell costs {1} less to cast for each opponent.)
Destroy all creatures.

Tranquility

Agent of Erebos

Constellation — Whenever Agent of Erebos or another enchantment you control enters, exile target player's graveyard.

Tranquil Path

Myojin of Cleansing Fire

Myojin of Cleansing Fire enters with a divinity counter on it if you cast it from your hand.
Myojin of Cleansing Fire has indestructible as long as it has a divinity counter on it.
Remove a divinity counter from Myojin of Cleansing Fire: Destroy all other creatures.

Fell the Mighty

Destroy all creatures with power greater than target creature's power.

Forced March

Destroy all creatures with mana value X or less.

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Nevinyrral's Disk

Nevinyrral's Disk enters tapped.
{1}, {T}: Destroy all artifacts, creatures, and enchantments.

Supreme Verdict

This spell can't be countered.
Destroy all creatures.

Plague Wind

Destroy all creatures you don't control. They can't be regenerated.

Fracturing Gust

Destroy all artifacts and enchantments. You gain 2 life for each permanent destroyed this way.

Paraselene

Destroy all enchantments. You gain 1 life for each enchantment destroyed this way.

Mogg Infestation

Destroy all creatures target player controls. For each creature that died this way, that player creates two 1/1 red Goblin creature tokens.

End Hostilities

Destroy all creatures and all permanents attached to creatures.

Breaking Point

Any player may have Breaking Point deal 6 damage to them. If no one does, destroy all creatures. Creatures destroyed this way can't be regenerated.

Wakening Sun's Avatar

When Wakening Sun's Avatar enters, if you cast it from your hand, destroy all non-Dinosaur creatures.

Kindred Dominance

Choose a creature type. Destroy all creatures that aren't of the chosen type.

March of Souls

Destroy all creatures. They can't be regenerated. For each creature destroyed this way, its controller creates a 1/1 white Spirit creature token with flying.

Decree of Annihilation

Exile all artifacts, creatures, and lands from the battlefield, all cards from all graveyards, and all cards from all hands.
Cycling {5}{R}{R} ({5}{R}{R}, Discard this card: Draw a card.)
When you cycle Decree of Annihilation, destroy all lands.

Bontu's Last Reckoning

Destroy all creatures. Lands you control don't untap during your next untap step.

Creeping Corrosion

Life's Finale

Destroy all creatures, then search target opponent's library for up to three creature cards and put them into their graveyard. Then that player shuffles.

Decree of Pain

Destroy all creatures. They can't be regenerated. Draw a card for each creature destroyed this way.
Cycling {3}{B}{B} ({3}{B}{B}, Discard this card: Draw a card.)
When you cycle Decree of Pain, all creatures get -2/-2 until end of turn.

Hammer Mage

{X}{R}, {T}, Discard a card: Destroy all artifacts with mana value X or less.

Pulverize

You may sacrifice two Mountains rather than pay this spell's mana cost.
Destroy all artifacts.

Multani's Decree

Destroy all enchantments. You gain 2 life for each enchantment destroyed this way.

Winds of Rath

Destroy all creatures that aren't enchanted. They can't be regenerated.

Child of Alara

Trample
When Child of Alara dies, destroy all nonland permanents. They can't be regenerated.

Rampage of the Clans

Destroy all artifacts and enchantments. For each permanent destroyed this way, its controller creates a 3/3 green Centaur creature token.

Akroma's Vengeance

Destroy all artifacts, creatures, and enchantments.
Cycling {3} ({3}, Discard this card: Draw a card.)

Novablast Wurm

Whenever Novablast Wurm attacks, destroy all other creatures.

Settle the Wreckage

Exile all attacking creatures target player controls. That player may search their library for that many basic land cards, put those cards onto the battlefield tapped, then shuffle.

Aether Snap

Remove all counters from all permanents and exile all tokens.

Tempest of Light

Dread Cacodemon

When Dread Cacodemon enters, if you cast it from your hand, destroy all creatures your opponents control, then tap all other creatures you control.

Planar Cleansing

Hythonia the Cruel

Deathtouch
{6}{B}{B}: Monstrosity 3. (If this creature isn't monstrous, put three +1/+1 counters on it and it becomes monstrous.)
When Hythonia the Cruel becomes monstrous, destroy all non-Gorgon creatures.

Desolation Giant

Kicker {W}{W} (You may pay an additional {W}{W} as you cast this spell.)
When Desolation Giant enters, destroy all other creatures you control. If it was kicked, destroy all other creatures instead.

Coercive Portal

Will of the council — At the beginning of your upkeep, starting with you, each player votes for carnage or homage. If carnage gets more votes, sacrifice Coercive Portal and destroy all nonland permanents. If homage gets more votes or the vote is tied, draw a card.

Descend upon the Sinful

Exile all creatures.
Delirium — Create a 4/4 white Angel creature token with flying if there are four or more card types among cards in your graveyard.

Tranquil Grove

{1}{G}{G}: Destroy all other enchantments.

Subterranean Tremors

Subterranean Tremors deals X damage to each creature without flying. If X is 4 or more, destroy all artifacts. If X is 8 or more, create an 8/8 red Lizard creature token.

Celestial Kirin

Flying
Whenever you cast a Spirit or Arcane spell, destroy all permanents with that spell's mana value.

Merciless Eviction

Choose one —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all planeswalkers.

Furnace Dragon

Affinity for artifacts (This spell costs {1} less to cast for each artifact you control.)
Flying
When Furnace Dragon enters, if you cast it from your hand, exile all artifacts.

Tranquil Domain

Time Wipe

Return a creature you control to its owner's hand, then destroy all creatures.

Phyrexian Rebirth

Destroy all creatures, then create an X/X colorless Phyrexian Horror artifact creature token, where X is the number of creatures destroyed this way.

Simple

Pure

Pure // Simple

Sunblast Angel

Flying
When Sunblast Angel enters, destroy all tapped creatures.

Kaya's Wrath

Destroy all creatures. You gain life equal to the number of creatures you controlled that were destroyed this way.

Fated Retribution

Destroy all creatures and planeswalkers. If it's your turn, scry 2.

Honor the Fallen

Exile all creature cards from all graveyards. You gain 1 life for each card exiled this way.