Perilous Vault

{5}, {T}, Exile Perilous Vault: Exile all nonland permanents.

Retribution of the Meek

Destroy all creatures with power 4 or greater. They can't be regenerated.

Fated Retribution

Destroy all creatures and planeswalkers. If it's your turn, scry 2. (Look at the top two cards of your library, then put any number of them on the bottom of your library and the rest on top in any order.)

Root Greevil

{2}{G}, {T}, Sacrifice Root Greevil: Destroy all enchantments of the color of your choice.

Aligned Hedron Network

When Aligned Hedron Network enters the battlefield, exile all creatures with power 5 or greater until Aligned Hedron Network leaves the battlefield. (Those creatures return under their owners' control.)

Fracturing Gust

Destroy all artifacts and enchantments. You gain 2 life for each permanent destroyed this way.

Bane of Progress

When Bane of Progress enters the battlefield, destroy all artifacts and enchantments. Put a +1/+1 counter on Bane of Progress for each permanent destroyed this way.

Fortunate Few

Choose a nonland permanent you don't control, then each other player chooses a nonland permanent they don't control that hasn't been chosen this way. Destroy all other nonland permanents.

Calming Verse

Destroy all enchantments you don't control. Then if you control an untapped land, destroy all enchantments you control.

Magus of the Disk

Magus of the Disk enters the battlefield tapped.
{1}, {T}: Destroy all artifacts, creatures, and enchantments.

Nevinyrral's Disk

Nevinyrral's Disk enters the battlefield tapped.
{1}, {T}: Destroy all artifacts, creatures, and enchantments.

Life's Finale

Destroy all creatures, then search target opponent's library for up to three creature cards and put them into their graveyard. Then that player shuffles.

Tempest of Light

Ritual of Soot

Destroy all creatures with mana value 3 or less.

Honor the Fallen

Exile all creature cards from all graveyards. You gain 1 life for each card exiled this way.

Plague Wind

Destroy all creatures you don't control. They can't be regenerated.

Scavenger Grounds

{T}: Add {C}.
{2}, {T}, Sacrifice a Desert: Exile all graveyards.

Cleansing Meditation

Destroy all enchantments.
Threshold — If seven or more cards are in your graveyard, instead destroy all enchantments, then return all cards in your graveyard destroyed this way to the battlefield.

Subterranean Tremors

Subterranean Tremors deals X damage to each creature without flying. If X is 4 or more, destroy all artifacts. If X is 8 or more, create an 8/8 red Lizard creature token.

Winds of Rath

Destroy all creatures that aren't enchanted. They can't be regenerated.

Creeping Corrosion

Armageddon

Kindred Dominance

Choose a creature type. Destroy all creatures that aren't of the chosen type.

Tranquility

Furnace Dragon

Affinity for artifacts (This spell costs {1} less to cast for each artifact you control.)
Flying
When Furnace Dragon enters the battlefield, if you cast it from your hand, exile all artifacts.

Planar Outburst

Destroy all nonland creatures.
Awaken 4—{5}{W}{W}{W} (If you cast this spell for {5}{W}{W}{W}, also put four +1/+1 counters on target land you control and it becomes a 0/0 Elemental creature with haste. It's still a land.)

Soulscour

Breaking Point

Any player may have Breaking Point deal 6 damage to them. If no one does, destroy all creatures. Creatures destroyed this way can't be regenerated.

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.

Decree of Annihilation

Exile all artifacts, creatures, and lands from the battlefield, all cards from all graveyards, and all cards from all hands.
Cycling {5}{R}{R} ({5}{R}{R}, Discard this card: Draw a card.)
When you cycle Decree of Annihilation, destroy all lands.

Deadly Tempest

Destroy all creatures. Each player loses life equal to the number of creatures they controlled that were destroyed this way.

Multani's Decree

Destroy all enchantments. You gain 2 life for each enchantment destroyed this way.

Settle the Wreckage

Exile all attacking creatures target player controls. That player may search their library for that many basic land cards, put those cards onto the battlefield tapped, then shuffle.

Martial Coup

Create X 1/1 white Soldier creature tokens. If X is 5 or more, destroy all other creatures.

Ravnica at War

Agent of Erebos

Constellation — Whenever Agent of Erebos or another enchantment enters the battlefield under your control, exile target player's graveyard.

Plague Boiler

At the beginning of your upkeep, put a plague counter on Plague Boiler.
{1}{B}{G}: Put a plague counter on Plague Boiler or remove a plague counter from it.
When Plague Boiler has three or more plague counters on it, sacrifice it. If you do, destroy all nonland permanents.

Kalemne's Captain

Vigilance
{5}{W}{W}: Monstrosity 3. (If this creature isn't monstrous, put three +1/+1 counters on it and it becomes monstrous.)
When Kalemne's Captain becomes monstrous, exile all artifacts and enchantments.

Wrath of God

Destroy all creatures. They can't be regenerated.

Reiver Demon

Flying
When Reiver Demon enters the battlefield, if you cast it from your hand, destroy all nonartifact, nonblack creatures. They can't be regenerated.

Planar Cleansing

Hush

Destroy all enchantments.
Cycling {2} ({2}, Discard this card: Draw a card.)

Desolation Giant

Kicker {W}{W} (You may pay an additional {W}{W} as you cast this spell.)
When Desolation Giant enters the battlefield, destroy all other creatures you control. If it was kicked, destroy all other creatures instead.

Sentinel Totem

When Sentinel Totem enters the battlefield, scry 1. (Look at the top card of your library. You may put that card on the bottom of your library.)
{T}, Exile Sentinel Totem: Exile all graveyards.

Child of Alara

Trample
When Child of Alara dies, destroy all nonland permanents. They can't be regenerated.

Jokulhaups

Destroy all artifacts, creatures, and lands. They can't be regenerated.

Tsunami

Dimensional Breach

Exile all permanents. For as long as any of those cards remain exiled, at the beginning of each player's upkeep, that player returns one of the exiled cards they own to the battlefield.

Phyrexian Scriptures

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — Put a +1/+1 counter on up to one target creature. That creature becomes an artifact in addition to its other types.
II — Destroy all nonartifact creatures.
III — Exile all opponents' graveyards.

Paraselene

Destroy all enchantments. You gain 1 life for each enchantment destroyed this way.

Tranquil Path

March of Souls

Destroy all creatures. They can't be regenerated. For each creature destroyed this way, its controller creates a 1/1 white Spirit creature token with flying.

Tranquil Grove

{1}{G}{G}: Destroy all other enchantments.

Decree of Pain

Destroy all creatures. They can't be regenerated. Draw a card for each creature destroyed this way.
Cycling {3}{B}{B} ({3}{B}{B}, Discard this card: Draw a card.)
When you cycle Decree of Pain, all creatures get -2/-2 until end of turn.

Overwhelming Forces

Destroy all creatures target opponent controls. Draw a card for each creature destroyed this way.

Mogg Infestation

Destroy all creatures target player controls. For each creature that died this way, that player creates two 1/1 red Goblin creature tokens.

Deathbringer Regent

Flying
When Deathbringer Regent enters the battlefield, if you cast it from your hand and there are five or more other creatures on the battlefield, destroy all other creatures.

In Garruk's Wake

Destroy all creatures you don't control and all planeswalkers you don't control.

Angel of the Dire Hour

Flash
Flying
When Angel of the Dire Hour enters the battlefield, if you cast it from your hand, exile all attacking creatures.

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Serene Heart

Relic of Progenitus

{T}: Target player exiles a card from their graveyard.
{1}, Exile Relic of Progenitus: Exile all graveyards. Draw a card.

Hammer Mage

{X}{R}, {T}, Discard a card: Destroy all artifacts with mana value X or less.

Simple

Pure

Pure // Simple

Ruination

Urza's Ruinous Blast

(You may cast a legendary sorcery only if you control a legendary creature or planeswalker.)
Exile all nonland permanents that aren't legendary.

Shatterstorm

Destroy all artifacts. They can't be regenerated.

Back to Nature

Dread Cacodemon

When Dread Cacodemon enters the battlefield, if you cast it from your hand, destroy all creatures your opponents control, then tap all other creatures you control.

Hythonia the Cruel

Deathtouch
{6}{B}{B}: Monstrosity 3. (If this creature isn't monstrous, put three +1/+1 counters on it and it becomes monstrous.)
When Hythonia the Cruel becomes monstrous, destroy all non-Gorgon creatures.

Kaya's Wrath

Destroy all creatures. You gain life equal to the number of creatures you controlled that were destroyed this way.

Planar Collapse

At the beginning of your upkeep, if there are four or more creatures on the battlefield, sacrifice Planar Collapse and destroy all creatures. They can't be regenerated.

Apocalypse

Exile all permanents. You discard your hand.

Serenity

At the beginning of your upkeep, destroy all artifacts and enchantments. They can't be regenerated.

Harsh Mercy

Each player chooses a creature type. Destroy all creatures that aren't of a type chosen this way. They can't be regenerated.

Sunscour

You may exile two white cards from your hand rather than pay this spell's mana cost.
Destroy all creatures.

Purify

Obliterate

This spell can't be countered.
Destroy all artifacts, creatures, and lands. They can't be regenerated.

Merciless Eviction

Choose one —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all planeswalkers.

Time Wipe

Return a creature you control to its owner's hand, then destroy all creatures.

Solar Tide

Choose one —
• Destroy all creatures with power 2 or less.
• Destroy all creatures with power 3 or greater.
Entwine—Sacrifice two lands. (Choose both if you pay the entwine cost.)

End Hostilities

Destroy all creatures and all permanents attached to creatures.

Final Judgment

Play of the Game

Assist (Another player can pay up to {6} of this spell's cost.)
Exile all nonland permanents.

Kirtar's Wrath

Destroy all creatures. They can't be regenerated.
Threshold — If seven or more cards are in your graveyard, instead destroy all creatures, then create two 1/1 white Spirit creature tokens with flying. Creatures destroyed this way can't be regenerated.

Coercive Portal

Will of the council — At the beginning of your upkeep, starting with you, each player votes for carnage or homage. If carnage gets more votes, sacrifice Coercive Portal and destroy all nonland permanents. If homage gets more votes or the vote is tied, draw a card.

Catastrophe

Destroy all lands or all creatures. Creatures destroyed this way can't be regenerated.

Day of Judgment

Damnation

Aether Snap

Remove all counters from all permanents and exile all tokens.

Sunblast Angel

Flying
When Sunblast Angel enters the battlefield, destroy all tapped creatures.

Elspeth Tirel

+2: You gain 1 life for each creature you control.
−2: Create three 1/1 white Soldier creature tokens.
−5: Destroy all other permanents except for lands and tokens.

Hour of Revelation

This spell costs {3} less to cast if there are ten or more nonland permanents on the battlefield.
Destroy all nonland permanents.

Forced March

Destroy all creatures with mana value X or less.

Morningtide

Supreme Verdict

This spell can't be countered.
Destroy all creatures.

False Prophet

When False Prophet dies, exile all creatures.

Tranquil Domain

Patrician's Scorn

If you've cast another white spell this turn, you may cast this spell without paying its mana cost.
Destroy all enchantments.

Rampage of the Clans

Destroy all artifacts and enchantments. For each permanent destroyed this way, its controller creates a 3/3 green Centaur creature token.

Novablast Wurm

Whenever Novablast Wurm attacks, destroy all other creatures.

Sublime Exhalation

Undaunted (This spell costs {1} less to cast for each opponent.)
Destroy all creatures.

Pulverize

You may sacrifice two Mountains rather than pay this spell's mana cost.
Destroy all artifacts.

Celestial Kirin

Flying
Whenever you cast a Spirit or Arcane spell, destroy all permanents with that spell's mana value.

Crux of Fate

Choose one —
• Destroy all Dragon creatures.
• Destroy all non-Dragon creatures.

Boompile

{T}: Flip a coin. If you win the flip, destroy all nonland permanents.

Descend upon the Sinful

Exile all creatures.
Delirium — Create a 4/4 white Angel creature token with flying if there are four or more card types among cards in your graveyard.

Hour of Reckoning

Convoke (Your creatures can help cast this spell. Each creature you tap while casting this spell pays for {1} or one mana of that creature's color.)
Destroy all nontoken creatures.

Rest in Peace

When Rest in Peace enters the battlefield, exile all graveyards.
If a card or token would be put into a graveyard from anywhere, exile it instead.