Arid Mesa

{T}, Pay 1 life, Sacrifice Arid Mesa: Search your library for a Mountain or Plains card, put it onto the battlefield, then shuffle.

Teferi's Protection

Until your next turn, your life total can't change and you gain protection from everything. All permanents you control phase out. (While they're phased out, they're treated as though they don't exist. They phase in before you untap during your untap step.)
Exile Teferi's Protection.

The Golden Throne

Arcane Life-support — If you would lose the game, instead exile The Golden Throne and your life total becomes 1.
A Thousand Souls Die Every Day — {T}, Sacrifice a creature: Add three mana in any combination of colors.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Caves of Koilos

{T}: Add {C}.
{T}: Add {W} or {B}. Caves of Koilos deals 1 damage to you.

Marshland Bloodcaster

Flying
{1}{B}, {T}: Rather than pay the mana cost of the next spell you cast this turn, you may pay life equal to that spell's mana value.

City of Brass

Whenever City of Brass becomes tapped, it deals 1 damage to you.
{T}: Add one mana of any color.

Manascape Refractor

Manascape Refractor enters tapped.
Manascape Refractor has all activated abilities of all lands on the battlefield.
You may spend mana as though it were mana of any color to pay the activation costs of Manascape Refractor's abilities.

Llanowar Wastes

{T}: Add {C}.
{T}: Add {B} or {G}. Llanowar Wastes deals 1 damage to you.

Dark Confidant

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Deflecting Swat

If you control a commander, you may cast this spell without paying its mana cost.
You may choose new targets for target spell or ability.

Sulfurous Springs

{T}: Add {C}.
{T}: Add {B} or {R}. Sulfurous Springs deals 1 damage to you.

Settle the Wreckage

Exile all attacking creatures target player controls. That player may search their library for that many basic land cards, put those cards onto the battlefield tapped, then shuffle.

Comet Storm

Multikicker {1} (You may pay an additional {1} any number of times as you cast this spell.)
Choose any target, then choose another target for each time this spell was kicked. Comet Storm deals X damage to each of them.

Temple Garden

({T}: Add {G} or {W}.)
As Temple Garden enters, you may pay 2 life. If you don't, it enters tapped.

Keen Duelist

At the beginning of your upkeep, you and target opponent each reveal the top card of your library. You each lose life equal to the mana value of the card revealed by the other player. You each put the card you revealed into your hand.

Exotic Orchard

{T}: Add one mana of any color that a land an opponent controls could produce.

Sylvan Library

At the beginning of your draw step, you may draw two additional cards. If you do, choose two cards in your hand drawn this turn. For each of those cards, pay 4 life or put the card on top of your library.

Ziatora's Proving Ground

({T}: Add {B}, {R}, or {G}.)
Ziatora's Proving Ground enters tapped.
Cycling {3} ({3}, Discard this card: Draw a card.)

Devour in Shadow

Destroy target creature. It can't be regenerated. You lose life equal to that creature's toughness.

Rakdos Signet

Angel's Grace

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
You can't lose the game this turn and your opponents can't win the game this turn. Until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.

Bountiful Promenade

Bountiful Promenade enters tapped unless you have two or more opponents.
{T}: Add {G} or {W}.

Fellwar Stone

Spectator Seating

Spectator Seating enters tapped unless you have two or more opponents.
{T}: Add {R} or {W}.

Heroic Intervention

Permanents you control gain hexproof and indestructible until end of turn.

Dragonlord Dromoka

This spell can't be countered.
Flying, lifelink
Your opponents can't cast spells during your turn.

Selesnya Signet

Arcane Signet

Phyrexian Processor

As Phyrexian Processor enters, pay any amount of life.
{4}, {T}: Create an X/X black Phyrexian Minion creature token, where X is the life paid as Phyrexian Processor entered.

Worship

If you control a creature, damage that would reduce your life total to less than 1 reduces it to 1 instead.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Fire Covenant

As an additional cost to cast this spell, pay X life.
Fire Covenant deals X damage divided as you choose among any number of target creatures.

Vault of Champions

Vault of Champions enters tapped unless you have two or more opponents.
{T}: Add {W} or {B}.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Boros Charm

Choose one —
• Boros Charm deals 4 damage to target player or planeswalker.
• Permanents you control gain indestructible until end of turn.
• Target creature gains double strike until end of turn.

Golgari Signet

Spire Garden

Spire Garden enters tapped unless you have two or more opponents.
{T}: Add {R} or {G}.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Stomping Ground

({T}: Add {R} or {G}.)
As Stomping Ground enters, you may pay 2 life. If you don't, it enters tapped.

Blood Crypt

({T}: Add {B} or {R}.)
As Blood Crypt enters, you may pay 2 life. If you don't, it enters tapped.

Mischievous Poltergeist

Flying
Pay 1 life: Regenerate Mischievous Poltergeist.

Infernal Grasp

Destroy target creature. You lose 2 life.

Clifftop Retreat

Clifftop Retreat enters tapped unless you control a Mountain or a Plains.
{T}: Add {R} or {W}.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Overgrown Tomb

({T}: Add {B} or {G}.)
As Overgrown Tomb enters, you may pay 2 life. If you don't, it enters tapped.

Night's Whisper

Wall of Blood

Defender (This creature can't attack.)
Pay 1 life: Wall of Blood gets +1/+1 until end of turn.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Orzhov Signet

Sol Ring

Near-Death Experience

At the beginning of your upkeep, if you have exactly 1 life, you win the game.

Dire Tactics

Exile target creature. If you don't control a Human, you lose life equal to that creature's toughness.

Commander's Sphere

{T}: Add one mana of any color in your commander's color identity.
Sacrifice Commander's Sphere: Draw a card.

Sunpetal Grove

Sunpetal Grove enters tapped unless you control a Forest or a Plains.
{T}: Add {G} or {W}.

Wrath of God

Destroy all creatures. They can't be regenerated.

Ikra Shidiqi, the Usurper

Menace
Whenever a creature you control deals combat damage to a player, you gain life equal to that creature's toughness.
Partner (You can have two commanders if both have partner.)

Stronghold Arena

Kicker {G} and/or {W} (You may pay an additional {G} and/or {W} as you cast this spell.)
When Stronghold Arena enters, you gain 3 life for each time it was kicked.
Whenever one or more creatures you control deal combat damage to a player, you may reveal the top card of your library and put it into your hand. If you do, you lose life equal to its mana value.

Sign in Blood

Target player draws two cards and loses 2 life.

Angel of Grace

Flash
Flying
When Angel of Grace enters, until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.
{4}{W}{W}, Exile Angel of Grace from your graveyard: Your life total becomes 10.

Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Isolated Chapel

Isolated Chapel enters tapped unless you control a Plains or a Swamp.
{T}: Add {W} or {B}.

Godless Shrine

({T}: Add {W} or {B}.)
As Godless Shrine enters, you may pay 2 life. If you don't, it enters tapped.

Stinging Study

You draw X cards and you lose X life, where X is the mana value of a commander you own on the battlefield or in the command zone.

Axis of Mortality

At the beginning of your upkeep, you may have two target players exchange life totals.

Thrun, the Last Troll

This spell can't be countered.
Hexproof (This creature can't be the target of spells or abilities your opponents control.)
{1}{G}: Regenerate Thrun, the Last Troll.

Blood Celebrant

{B}, Pay 1 life: Add one mana of any color.

Bruse Tarl, Boorish Herder

Whenever Bruse Tarl, Boorish Herder enters or attacks, target creature you control gains double strike and lifelink until end of turn.
Partner (You can have two commanders if both have partner.)

Swamp

Bloodstained Mire

{T}, Pay 1 life, Sacrifice Bloodstained Mire: Search your library for a Swamp or Mountain card, put it onto the battlefield, then shuffle.

Demon's Due

Scry 2, then draw two cards. You lose 2 life.

Phyrexian Delver

When Phyrexian Delver enters, return target creature card from your graveyard to the battlefield. You lose life equal to that card's mana value.

Greed

Jetmir's Garden

({T}: Add {R}, {G}, or {W}.)
Jetmir's Garden enters tapped.
Cycling {3} ({3}, Discard this card: Draw a card.)

Boros Signet

Bloodtracker

Flying
{B}, Pay 2 life: Put a +1/+1 counter on Bloodtracker.
When Bloodtracker leaves the battlefield, draw a card for each +1/+1 counter on it.

Plunge into Darkness

Choose one —
• Sacrifice any number of creatures. You gain 3 life for each creature sacrificed this way.
• Pay any amount of life, then look at that many cards from the top of your library. Put one of those cards into your hand and exile the rest.
Entwine {B} (Choose both if you pay the entwine cost.)

Verdant Catacombs

{T}, Pay 1 life, Sacrifice Verdant Catacombs: Search your library for a Swamp or Forest card, put it onto the battlefield, then shuffle.

Beast Within

Destroy target permanent. Its controller creates a 3/3 green Beast creature token.

Sacred Foundry

({T}: Add {R} or {W}.)
As Sacred Foundry enters, you may pay 2 life. If you don't, it enters tapped.

Path to Exile

Exile target creature. Its controller may search their library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Black Market Connections

At the beginning of your first main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It has every creature type.)

Dark Tutelage

Marsh Flats

{T}, Pay 1 life, Sacrifice Marsh Flats: Search your library for a Plains or Swamp card, put it onto the battlefield, then shuffle.

Brushland

{T}: Add {C}.
{T}: Add {G} or {W}. Brushland deals 1 damage to you.

Forest

Return to Nature

Choose one —
• Destroy target artifact.
• Destroy target enchantment.
• Exile target card from a graveyard.

Undergrowth Stadium

Undergrowth Stadium enters tapped unless you have two or more opponents.
{T}: Add {B} or {G}.

Wooded Foothills

{T}, Pay 1 life, Sacrifice Wooded Foothills: Search your library for a Mountain or Forest card, put it onto the battlefield, then shuffle.

Deadly Tempest

Destroy all creatures. Each player loses life equal to the number of creatures they controlled that were destroyed this way.

Beledros Witherbloom

Flying
At the beginning of each upkeep, create a 1/1 black and green Pest creature token with "When this creature dies, you gain 1 life."
Pay 10 life: Untap all lands you control. Activate only once each turn.

Savai Triome

({T}: Add {R}, {W}, or {B}.)
Savai Triome enters tapped.
Cycling {3} ({3}, Discard this card: Draw a card.)

Eternal Witness

When Eternal Witness enters, you may return target card from your graveyard to your hand.

Indatha Triome

({T}: Add {W}, {B}, or {G}.)
Indatha Triome enters tapped.
Cycling {3} ({3}, Discard this card: Draw a card.)

Shadow Prophecy

Domain — Look at the top X cards of your library, where X is the number of basic land types among lands you control. Put up to two of them into your hand and the rest into your graveyard. You lose 2 life.

Mountain

Mana Confluence

{T}, Pay 1 life: Add one mana of any color.

Windswept Heath

{T}, Pay 1 life, Sacrifice Windswept Heath: Search your library for a Forest or Plains card, put it onto the battlefield, then shuffle.