Planar Collapse

At the beginning of your upkeep, if there are four or more creatures on the battlefield, sacrifice Planar Collapse and destroy all creatures. They can't be regenerated.

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.

Fated Retribution

Destroy all creatures and planeswalkers. If it's your turn, scry 2.

Divine Reckoning

Each player chooses a creature they control. Destroy the rest.
Flashback {5}{W}{W} (You may cast this card from your graveyard for its flashback cost. Then exile it.)

Sublime Exhalation

Undaunted (This spell costs {1} less to cast for each opponent.)
Destroy all creatures.

Doomskar

Destroy all creatures.
Foretell {1}{W}{W} (During your turn, you may pay {2} and exile this card from your hand face down. Cast it on a later turn for its foretell cost.)

Avacyn, Angel of Hope

Flying, vigilance, indestructible
Other permanents you control have indestructible.

Cast Off

Destroy all non-Giant creatures. (Then exile this card. You may cast the creature later from exile.)

Realm-Cloaked Giant

Realm-Cloaked Giant // Cast Off

Damning Verdict

Destroy all creatures with no counters on them.

Promise of Loyalty

Each player puts a vow counter on a creature they control and sacrifices the rest. Each of those creatures can't attack you or planeswalkers you control for as long as it has a vow counter on it.

Urza's Sylex

{2}{W}{W}, {T}, Exile Urza's Sylex: Each player chooses six lands they control. Destroy all other permanents. Activate only as a sorcery.
When Urza's Sylex is put into exile from the battlefield, you may pay {2}. If you do, search your library for a planeswalker card, reveal it, put it into your hand, then shuffle.

Tragic Arrogance

For each player, you choose from among the permanents that player controls an artifact, a creature, an enchantment, and a planeswalker. Then each player sacrifices all other nonland permanents they control.

Ondu Skyruins

Ondu Skyruins enters tapped.
{T}: Add {W}.

Ondu Inversion

Ondu Inversion // Ondu Skyruins

Day of Judgment

Ajani, Strength of the Pride

+1: You gain life equal to the number of creatures you control plus the number of planeswalkers you control.
−2: Create a 2/2 white Cat Soldier creature token named Ajani's Pridemate with "Whenever you gain life, put a +1/+1 counter on Ajani's Pridemate."
0: If you have at least 15 life more than your starting life total, exile Ajani, Strength of the Pride and each artifact and creature your opponents control.

Slash the Ranks

Destroy all creatures and planeswalkers except for commanders.

The Battle of Bywater

Destroy all creatures with power 3 or greater. Then create a Food token for each creature you control. (It's an artifact with "{2}, {T}, Sacrifice this artifact: You gain 3 life.")

Phyrexian Rebirth

Destroy all creatures, then create an X/X colorless Phyrexian Horror artifact creature token, where X is the number of creatures destroyed this way.

Spirit

Dawn

Aftermath (Cast this spell only from your graveyard. Then exile it.)
Return all creature cards with power 2 or less from your graveyard to your hand.

Dusk

Destroy all creatures with power 3 or greater.

Dusk // Dawn

Myojin of Cleansing Fire

Myojin of Cleansing Fire enters with a divinity counter on it if you cast it from your hand.
Myojin of Cleansing Fire has indestructible as long as it has a divinity counter on it.
Remove a divinity counter from Myojin of Cleansing Fire: Destroy all other creatures.

Akroma's Vengeance

Destroy all artifacts, creatures, and enchantments.
Cycling {3} ({3}, Discard this card: Draw a card.)

Mageta the Lion

{2}{W}{W}, {T}, Discard two cards: Destroy all creatures except for Mageta the Lion. Those creatures can't be regenerated.

Snow-Covered Plains

Phyrexian Mite

Toxic 1 (Players dealt combat damage by this creature also get a poison counter.)
This creature can't block.

Expel the Interlopers

Choose a number between 0 and 10. Destroy all creatures with power greater than or equal to the chosen number.

Worldslayer

Whenever equipped creature deals combat damage to a player, destroy all permanents other than Worldslayer.
Equip {5} ({5}: Attach to target creature you control. Equip only as a sorcery.)

Planar Cleansing

Wakening Sun's Avatar

When Wakening Sun's Avatar enters, if you cast it from your hand, destroy all non-Dinosaur creatures.

Vanquish the Horde

This spell costs {1} less to cast for each creature on the battlefield.
Destroy all creatures.

Sandswirl Wanderglyph

Flying
Whenever an opponent casts a spell during their turn, they can't attack you or planeswalkers you control this turn.
Each opponent who attacked you or a planeswalker you control this turn can't cast spells.

Unstable Glyphbridge

When Unstable Glyphbridge enters, if you cast it, for each player, choose a creature with power 2 or less that player controls. Then destroy all creatures except creatures chosen this way.
Craft with artifact {3}{W}{W} ({3}{W}{W}, Exile this artifact, Exile another artifact you control or an artifact card from your graveyard: Return this card transformed under its owner's control. Craft only as a sorcery.)

Unstable Glyphbridge // Sandswirl Wanderglyph

Wrath of God

Destroy all creatures. They can't be regenerated.

Martial Coup

Create X 1/1 white Soldier creature tokens. If X is 5 or more, destroy all other creatures.

Mass Calcify

Nevinyrral's Disk

Nevinyrral's Disk enters tapped.
{1}, {T}: Destroy all artifacts, creatures, and enchantments.

The Eternal Wanderer

No more than one creature can attack The Eternal Wanderer each combat.
+1: Exile up to one target artifact or creature. Return that card to the battlefield under its owner's control at the beginning of that player's next end step.
0: Create a 2/2 white Samurai creature token with double strike.
−4: For each player, choose a creature that player controls. Each player sacrifices all creatures they control not chosen this way.

Slaughter the Strong

Each player chooses any number of creatures they control with total power 4 or less, then sacrifices all other creatures they control.

The Night of the Doctor

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after II.)
I — Destroy all creatures.
II — Return target legendary creature card from your graveyard to the battlefield. Put your choice of a first strike, vigilance, or lifelink counter on it.

Crisis of Conscience

Choose one —
• Destroy all tokens.
• Destroy all nonland, nontoken permanents.

Fell the Mighty

Destroy all creatures with power greater than target creature's power.

Single Combat

Each player chooses a creature or planeswalker they control, then sacrifices the rest. Players can't cast creature or planeswalker spells until the end of your next turn.

White Sun's Twilight

You gain X life. Create X 1/1 colorless Phyrexian Mite artifact creature tokens with toxic 1 and "This creature can't block." If X is 5 or more, destroy all other creatures. (Players dealt combat damage by a creature with toxic 1 also get a poison counter.)

No Witnesses

Each player who controls the most creatures investigates. Then destroy all creatures. (To investigate, create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")

Paraselene

Destroy all enchantments. You gain 1 life for each enchantment destroyed this way.

Righteous Fury

Destroy all tapped creatures. You gain 2 life for each creature destroyed this way.

Terminus

Put all creatures on the bottom of their owners' libraries.
Miracle {W} (You may cast this card for its miracle cost when you draw it if it's the first card you drew this turn.)

Final Showdown

Spree (Choose one or more additional costs.)
+ {1} — All creatures lose all abilities until end of turn.
+ {1} — Choose a creature you control. It gains indestructible until end of turn.
+ {3}{W}{W} — Destroy all creatures.

Scourglass

{T}, Sacrifice Scourglass: Destroy all permanents except for artifacts and lands. Activate only during your upkeep.

Samurai

Don't Move

Destroy all tapped creatures. Until your next turn, whenever a creature becomes tapped, destroy it.

Elspeth Tirel

+2: You gain 1 life for each creature you control.
−2: Create three 1/1 white Soldier creature tokens.
−5: Destroy all other permanents except for lands and tokens.

Devastating Mastery

You may pay {2}{W}{W} rather than pay this spell's mana cost.
If the {2}{W}{W} cost was paid, an opponent chooses up to two nonland permanents they control and returns them to their owner's hand.
Destroy all nonland permanents.

Hour of Revelation

This spell costs {3} less to cast if there are ten or more nonland permanents on the battlefield.
Destroy all nonland permanents.

End Hostilities

Destroy all creatures and all permanents attached to creatures.

Rout

You may cast Rout as though it had flash if you pay {2} more to cast it. (You may cast it any time you could cast an instant.)
Destroy all creatures. They can't be regenerated.

Magus of the Disk

Magus of the Disk enters tapped.
{1}, {T}: Destroy all artifacts, creatures, and enchantments.

Icatian Store

Icatian Store enters tapped.
You may choose not to untap Icatian Store during your untap step.
At the beginning of your upkeep, if Icatian Store is tapped, put a storage counter on it.
{T}, Remove any number of storage counters from Icatian Store: Add {W} for each storage counter removed this way.

Food

{2}, {T}, Sacrifice this artifact: You gain 3 life.

Boompile

{T}: Flip a coin. If you win the flip, destroy all nonland permanents.

Winds of Rath

Destroy all creatures that aren't enchanted. They can't be regenerated.

Elspeth, Sun's Champion Emblem

Creatures you control get +2/+2 and have flying.

Phyrexian Horror

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Ajani's Pridemate

Whenever you gain life, put a +1/+1 counter on Ajani's Pridemate.

Elspeth, Sun's Champion

+1: Create three 1/1 white Soldier creature tokens.
−3: Destroy all creatures with power 4 or greater.
−7: You get an emblem with "Creatures you control get +2/+2 and have flying."

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Clue

{2}, Sacrifice this artifact: Draw a card.

Soldier

Hour of Reckoning

Convoke (Your creatures can help cast this spell. Each creature you tap while casting this spell pays for {1} or one mana of that creature's color.)
Destroy all nontoken creatures.

Organic Extinction

Improvise (Your artifacts can help cast this spell. Each artifact you tap after you're done activating mana abilities pays for {1}.)
Destroy all nonartifact creatures.

Catastrophe

Destroy all lands or all creatures. Creatures destroyed this way can't be regenerated.

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Kirtar's Wrath

Destroy all creatures. They can't be regenerated.
Threshold — If seven or more cards are in your graveyard, instead destroy all creatures, then create two 1/1 white Spirit creature tokens with flying. Creatures destroyed this way can't be regenerated.