Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

River Song

Meet in Reverse — You draw cards from the bottom of your library rather than the top.
Spoilers — Whenever an opponent scries, surveils, or searches their library, put a +1/+1 counter on River Song. Then River Song deals damage to that player equal to its power.

Feast of Sanity

Whenever you discard a card, Feast of Sanity deals 1 damage to any target and you gain 1 life.

Strix Serenade

Counter target artifact, creature, or planeswalker spell. Its controller creates a 2/2 blue Bird creature token with flying.

Wheel of Fortune

Each player discards their hand, then draws seven cards.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Geth's Grimoire

Whenever an opponent discards a card, you may draw a card.

Ob Nixilis, the Hate-Twisted

Whenever an opponent draws a card, Ob Nixilis, the Hate-Twisted deals 1 damage to that player.
−2: Destroy target creature. Its controller draws two cards.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Kaervek the Merciless

Whenever an opponent casts a spell, Kaervek the Merciless deals damage equal to that spell's mana value to any target.

Tergrid's Lantern

{T}: Target player loses 3 life unless they sacrifice a nonland permanent of their choice or discard a card.
{3}{B}: Untap Tergrid's Lantern.

Tergrid, God of Fright

Menace
Whenever an opponent sacrifices a nontoken permanent or discards a permanent card, you may put that card from a graveyard onto the battlefield under your control.

Tergrid, God of Fright // Tergrid's Lantern

Rielle, the Everwise

Rielle, the Everwise gets +1/+0 for each instant and sorcery card in your graveyard.
Whenever you discard one or more cards for the first time each turn, draw that many cards.

Temple of the Dead

(Transforms from Aclazotz, Deepest Betrayal.)
{T}: Add {B}.
{2}{B}, {T}: Transform Temple of the Dead. Activate only if a player has one or fewer cards in hand and only as a sorcery.

Aclazotz, Deepest Betrayal

Flying, lifelink
Whenever Aclazotz attacks, each opponent discards a card. For each opponent who can't, you draw a card.
Whenever an opponent discards a land card, create a 1/1 black Bat creature token with flying.
When Aclazotz dies, return it to the battlefield tapped and transformed under its owner's control.

Aclazotz, Deepest Betrayal // Temple of the Dead

Nezahal, Primal Tide

This spell can't be countered.
You have no maximum hand size.
Whenever an opponent casts a noncreature spell, draw a card.
Discard three cards: Exile Nezahal, Primal Tide. Return it to the battlefield tapped under its owner's control at the beginning of the next end step.

Talisman of Indulgence

{T}: Add {C}.
{T}: Add {B} or {R}. Talisman of Indulgence deals 1 damage to you.

Memory Erosion

Whenever an opponent casts a spell, that player mills two cards.

Liliana's Caress

Whenever an opponent discards a card, that player loses 2 life.

Chandra's Spitfire

Flying
Whenever an opponent is dealt noncombat damage, Chandra's Spitfire gets +3/+0 until end of turn.

Kederekt Parasite

Whenever an opponent draws a card, if you control a red permanent, you may have Kederekt Parasite deal 1 damage to that player.

Niv-Mizzet, Parun

This spell can't be countered.
Flying
Whenever you draw a card, Niv-Mizzet, Parun deals 1 damage to any target.
Whenever a player casts an instant or sorcery spell, you draw a card.

Echo of Eons

Each player shuffles their hand and graveyard into their library, then draws seven cards.
Flashback {2}{U} (You may cast this card from your graveyard for its flashback cost. Then exile it.)

Swan Song

Counter target enchantment, instant, or sorcery spell. Its controller creates a 2/2 blue Bird creature token with flying.

Deflecting Swat

If you control a commander, you may cast this spell without paying its mana cost.
You may choose new targets for target spell or ability.

Stifle

Counter target activated or triggered ability. (Mana abilities can't be targeted.)

Mayhem Devil

Whenever a player sacrifices a permanent, Mayhem Devil deals 1 damage to any target.

Mystic Remora

Cumulative upkeep {1} (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)
Whenever an opponent casts a noncreature spell, you may draw a card unless that player pays {4}.

Nekusar, the Mindrazer

At the beginning of each player's draw step, that player draws an additional card.
Whenever an opponent draws a card, Nekusar, the Mindrazer deals 1 damage to that player.

Fierce Guardianship

If you control a commander, you may cast this spell without paying its mana cost.
Counter target noncreature spell.

Rhystic Study

Whenever an opponent casts a spell, you may draw a card unless that player pays {1}.

Wheel of Misfortune

Each player secretly chooses a number 0 or greater, then all players reveal those numbers simultaneously and determine the highest and lowest numbers revealed this way. Wheel of Misfortune deals damage equal to the highest number to each player who chose that number. Each player who didn't choose the lowest number discards their hand, then draws seven cards.

Dark Deal

Each player discards all the cards in their hand, then draws that many cards minus one.

Arcane Denial

Counter target spell. Its controller may draw up to two cards at the beginning of the next turn's upkeep.
You draw a card at the beginning of the next turn's upkeep.

Leyline of Anticipation

If Leyline of Anticipation is in your opening hand, you may begin the game with it on the battlefield.
You may cast spells as though they had flash.

Talisman of Creativity

{T}: Add {C}.
{T}: Add {U} or {R}. Talisman of Creativity deals 1 damage to you.

Kraum, Ludevic's Opus

Flying, haste
Whenever an opponent casts their second spell each turn, draw a card.
Partner (You can have two commanders if both have partner.)

Harsh Mentor

Whenever an opponent activates an ability of an artifact, creature, or land on the battlefield, if it isn't a mana ability, Harsh Mentor deals 2 damage to that player.

Counterspell

Teferi's Puzzle Box

At the beginning of each player's draw step, that player puts the cards in their hand on the bottom of their library in any order, then draws that many cards.

Forced Fruition

Whenever an opponent casts a spell, that player draws seven cards.

An Offer You Can't Refuse

Counter target noncreature spell. Its controller creates two Treasure tokens. (They're artifacts with "{T}, Sacrifice this token: Add one mana of any color.")

Decaying Time Loop

Discard all the cards in your hand, then draw that many cards.
Retrace (You may cast this card from your graveyard by discarding a land card in addition to paying its other costs.)

Bone Miser

Whenever you discard a creature card, create a 2/2 black Zombie creature token.
Whenever you discard a land card, add {B}{B}.
Whenever you discard a noncreature, nonland card, draw a card.

Dockside Extortionist

When Dockside Extortionist enters, create X Treasure tokens, where X is the number of artifacts and enchantments your opponents control. (Treasure tokens are artifacts with "{T}, Sacrifice this artifact: Add one mana of any color.")

Day's Undoing

Each player shuffles their hand and graveyard into their library, then draws seven cards. If it's your turn, end the turn. (Exile all spells and abilities from the stack, including this card. Discard down to your maximum hand size. Damage wears off, and "this turn" and "until end of turn" effects end.)

Sol Ring

Fate Unraveler

Whenever an opponent draws a card, Fate Unraveler deals 1 damage to that player.

Glint-Horn Buccaneer

Haste
Whenever you discard a card, Glint-Horn Buccaneer deals 1 damage to each opponent.
{1}{R}, Discard a card: Draw a card. Activate only if Glint-Horn Buccaneer is attacking.

Deadly Rollick

If you control a commander, you may cast this spell without paying its mana cost.
Exile target creature.

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Talion, the Kindly Lord

Flying
As Talion, the Kindly Lord enters, choose a number between 1 and 10.
Whenever an opponent casts a spell with mana value, power, or toughness equal to the chosen number, that player loses 2 life and you draw a card.

Windfall

Each player discards their hand, then draws cards equal to the greatest number of cards a player discarded this way.

Flare of Duplication

You may sacrifice a nontoken red creature rather than pay this spell's mana cost.
Copy target instant or sorcery spell. You may choose new targets for the copy.

Jin-Gitaxias, Progress Tyrant

Whenever you cast an artifact, instant, or sorcery spell, copy that spell. You may choose new targets for the copy. This ability triggers only once each turn. (A copy of a permanent spell becomes a token.)
Whenever an opponent casts an artifact, instant, or sorcery spell, counter that spell. This ability triggers only once each turn.

Ob Nixilis, Captive Kingpin

Flying, trample
Whenever one or more opponents each lose exactly 1 life, put a +1/+1 counter on Ob Nixilis, Captive Kingpin. Exile the top card of your library. Until your next end step, you may play that card.

Winds of Change

Each player shuffles the cards from their hand into their library, then draws that many cards.

Faerie Mastermind

Flash
Flying
Whenever an opponent draws their second card each turn, you draw a card.
{3}{U}: Each player draws a card.

Pyre of the World Tree

Discard a land card: Pyre of the World Tree deals 2 damage to any target.
Whenever you discard a land card, exile the top card of your library. You may play that card this turn.

Invasion of Kaldheim

(As a Siege enters, choose an opponent to protect it. You and others can attack it. When it's defeated, exile it, then cast it transformed.)
When Invasion of Kaldheim enters, exile all cards from your hand, then draw that many cards. Until the end of your next turn, you may play cards exiled this way.

Invasion of Kaldheim // Pyre of the World Tree

Talisman of Dominance

{T}: Add {C}.
{T}: Add {U} or {B}. Talisman of Dominance deals 1 damage to you.

Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on Bloodchief Ascension. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if Bloodchief Ascension has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Trickbind

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
Counter target activated or triggered ability. If a permanent's ability is countered this way, activated abilities of that permanent can't be activated this turn. (Mana abilities can't be targeted.)

Xander's Lounge

({T}: Add {U}, {B}, or {R}.)
Xander's Lounge enters tapped.
Cycling {3} ({3}, Discard this card: Draw a card.)

Flare of Denial

You may sacrifice a nontoken blue creature rather than pay this spell's mana cost.
Counter target spell.

Timetwister

Each player shuffles their hand and graveyard into their library, then draws seven cards. (Then put Timetwister into its owner's graveyard.)

Relic of Sauron

{T}: Add two mana in any combination of {U}, {B}, and/or {R}.
{3}, {T}: Draw two cards, then discard a card.

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Waste Not

Whenever an opponent discards a creature card, create a 2/2 black Zombie creature token.
Whenever an opponent discards a land card, add {B}{B}.
Whenever an opponent discards a noncreature, nonland card, draw a card.

Mindcrank

Whenever an opponent loses life, that player mills that many cards. (Damage causes loss of life.)

Orcish Bowmasters

Flash
When Orcish Bowmasters enters and whenever an opponent draws a card except the first one they draw in each of their draw steps, Orcish Bowmasters deals 1 damage to any target. Then amass Orcs 1.

Ghyrson Starn, Kelermorph

Ward {2} (Whenever this creature becomes the target of a spell or ability an opponent controls, counter it unless that player pays {2}.)
Three Autostubs — Whenever another source you control deals exactly 1 damage to a permanent or player, Ghyrson Starn, Kelermorph deals 2 damage to that permanent or player.