Smallpox

Each player loses 1 life, discards a card, sacrifices a creature of their choice, then sacrifices a land of their choice.

Liliana's Caress

Whenever an opponent discards a card, that player loses 2 life.

Raiders' Wake

Whenever an opponent discards a card, that player loses 2 life.
Raid — At the beginning of your end step, if you attacked this turn, target opponent discards a card.

Stabwhisker the Odious

At the beginning of each opponent's upkeep, that player loses 1 life for each card fewer than three in their hand.

Nezumi Shortfang

{1}{B}, {T}: Target opponent discards a card. Then if that player has no cards in hand, flip this creature.

Nezumi Shortfang // Stabwhisker the Odious

Capital Punishment

Council's dilemma — Starting with you, each player votes for death or taxes. Each opponent sacrifices a creature of their choice for each death vote and discards a card for each taxes vote.

Chain of Smog

Target player discards two cards. That player may copy this spell and may choose a new target for that copy.

Stronghold Rats

Shadow (This creature can block or be blocked by only creatures with shadow.)
Whenever this creature deals combat damage to a player, each player discards a card.

Davriel, Rogue Shadowmage

At the beginning of each opponent's upkeep, if that player has one or fewer cards in hand, Davriel deals 2 damage to them.
−1: Target player discards a card.

Swamp

Dark Deal

Each player discards all the cards in their hand, then draws that many cards minus one.

Mind Rake

Target player discards two cards.
Overload {1}{B} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Creeping Dread

At the beginning of your upkeep, each player discards a card. Each opponent who discarded a card that shares a card type with the card you discarded loses 3 life. (Players reveal the discarded cards simultaneously.)

Megrim

Whenever an opponent discards a card, this enchantment deals 2 damage to that player.

Quest for the Nihil Stone

Whenever an opponent discards a card, you may put a quest counter on this enchantment.
At the beginning of each opponent's upkeep, if that player has no cards in hand and this enchantment has two or more quest counters on it, you may have that player lose 5 life.

Asylum Visitor

At the beginning of each player's upkeep, if that player has no cards in hand, you draw a card and you lose 1 life.
Madness {1}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Waste Not

Whenever an opponent discards a creature card, create a 2/2 black Zombie creature token.
Whenever an opponent discards a land card, add {B}{B}.
Whenever an opponent discards a noncreature, nonland card, draw a card.

Caligo Skin-Witch

Kicker {3}{B} (You may pay an additional {3}{B} as you cast this spell.)
When this creature enters, if it was kicked, each opponent discards two cards.

Arterial Flow

Each opponent discards two cards. If you control a Vampire, each opponent loses 2 life and you gain 2 life.

Syphon Mind

Each other player discards a card. You draw a card for each card discarded this way.

Tasigur's Cruelty

Delve (Each card you exile from your graveyard while casting this spell pays for {1}.)
Each opponent discards two cards.

Miasmic Mummy

When this creature enters, each player discards a card.

Unnerve

Oona's Prowler

Flying
Discard a card: This creature gets -2/-0 until end of turn. Any player may activate this ability.

Delirium Skeins

Words of Waste

{1}: The next time you would draw a card this turn, each opponent discards a card instead.

Mind Shatter

Target player discards X cards at random.

Necrogen Mists

At the beginning of each player's upkeep, that player discards a card.

Bottomless Pit

At the beginning of each player's upkeep, that player discards a card at random.

Fell Specter

Flying
When this creature enters, target opponent discards a card.
Whenever an opponent discards a card, that player loses 2 life.

Cunning Lethemancer

At the beginning of your upkeep, each player discards a card.

Bite of the Black Rose

Will of the council — Starting with you, each player votes for sickness or psychosis. If sickness gets more votes, creatures your opponents control get -2/-2 until end of turn. If psychosis gets more votes or the vote is tied, each opponent discards two cards.

Vicious Rumors

Vicious Rumors deals 1 damage to each opponent. Each opponent discards a card, then mills a card. You gain 1 life.

Raven's Crime

Target player discards a card.
Retrace (You may cast this card from your graveyard by discarding a land card in addition to paying its other costs.)

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent of their choice or discards a card.

Awaken the Erstwhile

Each player discards all the cards in their hand, then creates that many 2/2 black Zombie creature tokens.

Mindslicer

When this creature dies, each player discards their hand.

Mind Peel

Buyback {2}{B}{B} (You may pay an additional {2}{B}{B} as you cast this spell. If you do, put this card into your hand as it resolves.)
Target player discards a card.

Davriel's Shadowfugue

Target player discards two cards and loses 2 life.

Oppression

Whenever a player casts a spell, that player discards a card.

Shrieking Affliction

At the beginning of each opponent's upkeep, if that player has one or fewer cards in hand, they lose 3 life.