Sanctum of Stone Fangs

At the beginning of your first main phase, each opponent loses X life and you gain X life, where X is the number of Shrines you control.

Malakir Blood-Priest

When Malakir Blood-Priest enters, each opponent loses X life and you gain X life, where X is the number of creatures in your party. (Your party consists of up to one each of Cleric, Rogue, Warrior, and Wizard.)

Lathril, Blade of the Elves

Menace
Whenever Lathril, Blade of the Elves deals combat damage to a player, create that many 1/1 green Elf Warrior creature tokens.
{T}, Tap ten untapped Elves you control: Each opponent loses 10 life and you gain 10 life.

Trinisphere

As long as Trinisphere is untapped, each spell that would cost less than three mana to cast costs three mana to cast. (Additional mana in the cost may be paid with any color of mana or colorless mana. For example, a spell that would cost {1}{B} to cast costs {2}{B} to cast instead.)

Pulse Tracker

Whenever Pulse Tracker attacks, each opponent loses 1 life.

Reclamation Sage

When Reclamation Sage enters, you may destroy target artifact or enchantment.

Undergrowth Stadium

Undergrowth Stadium enters tapped unless you have two or more opponents.
{T}: Add {B} or {G}.

Lodestone Golem

Nonartifact spells cost {1} more to cast.

Psychosis Crawler

Psychosis Crawler's power and toughness are each equal to the number of cards in your hand.
Whenever you draw a card, each opponent loses 1 life.

Endbringer

Untap Endbringer during each other player's untap step.
{T}: Endbringer deals 1 damage to any target.
{C}, {T}: Target creature can't attack or block this turn.
{C}{C}, {T}: Draw a card.

Slaughter Pact

Destroy target nonblack creature.
At the beginning of your next upkeep, pay {2}{B}. If you don't, you lose the game.

Vendetta

Destroy target nonblack creature. It can't be regenerated. You lose life equal to that creature's toughness.

Aurora of Emrakul

Flying, deathtouch
Whenever Aurora of Emrakul attacks, each opponent loses 3 life.

Cryptolith Fragment

Cryptolith Fragment enters tapped.
{T}: Add one mana of any color. Each player loses 1 life.
At the beginning of your upkeep, if each player has 10 or less life, transform Cryptolith Fragment.

Cryptolith Fragment // Aurora of Emrakul

Abrupt Decay

This spell can't be countered.
Destroy target nonland permanent with mana value 3 or less.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Force of Vigor

If it's not your turn, you may exile a green card from your hand rather than pay this spell's mana cost.
Destroy up to two target artifacts and/or enchantments.

Soul Shatter

Each opponent sacrifices a creature or planeswalker with the highest mana value among creatures and planeswalkers they control.

Cauldron Familiar

When Cauldron Familiar enters, each opponent loses 1 life and you gain 1 life.
Sacrifice a Food: Return Cauldron Familiar from your graveyard to the battlefield.

Ugin, the Ineffable

Colorless spells you cast cost {2} less to cast.
+1: Exile the top card of your library face down and look at it. Create a 2/2 colorless Spirit creature token. When that token leaves the battlefield, put the exiled card into your hand.
−3: Destroy target permanent that's one or more colors.

Walking Ballista

Walking Ballista enters with X +1/+1 counters on it.
{4}: Put a +1/+1 counter on Walking Ballista.
Remove a +1/+1 counter from Walking Ballista: It deals 1 damage to any target.

Damnation

Destroy all creatures. They can't be regenerated.

Bontu's Monument

Black creature spells you cast cost {1} less to cast.
Whenever you cast a creature spell, each opponent loses 1 life and you gain 1 life.

Karn, the Great Creator

Activated abilities of artifacts your opponents control can't be activated.
+1: Until your next turn, up to one target noncreature artifact becomes an artifact creature with power and toughness each equal to its mana value.
−2: You may reveal an artifact card you own from outside the game or choose a face-up artifact card you own in exile. Put that card into your hand.

Tevesh Szat, Doom of Fools

+2: Create two 0/1 black Thrull creature tokens.
+1: You may sacrifice another creature or planeswalker. If you do, draw two cards, then draw another card if the sacrificed permanent was a commander.
−10: Gain control of all commanders. Put all commanders from the command zone onto the battlefield under your control.
Tevesh Szat, Doom of Fools can be your commander.
Partner

Fyndhorn Elves

Wound Reflection

At the beginning of each end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

God-Pharaoh's Statue

Spells your opponents cast cost {2} more to cast.
At the beginning of your end step, each opponent loses 1 life.

Arbor Elf

Deathrite Shaman

{T}: Exile target land card from a graveyard. Add one mana of any color.
{B}, {T}: Exile target instant or sorcery card from a graveyard. Each opponent loses 2 life.
{G}, {T}: Exile target creature card from a graveyard. You gain 2 life.

Skull Storm

When you cast this spell, copy it for each time you've cast your commander from the command zone this game.
Each opponent sacrifices a creature. Each opponent who can't loses half their life, rounded up.

Pernicious Deed

{X}, Sacrifice Pernicious Deed: Destroy each artifact, creature, and enchantment with mana value X or less.

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent or discards a card.

Manglehorn

When Manglehorn enters, you may destroy target artifact.
Artifacts your opponents control enter tapped.

Gonti, Lord of Luxury

Deathtouch
When Gonti, Lord of Luxury enters, look at the top four cards of target opponent's library, exile one of them face down, then put the rest on the bottom of that library in a random order. You may cast that card for as long as it remains exiled, and mana of any type can be spent to cast that spell.

Void Winnower

Your opponents can't cast spells with even mana values. (Zero is even.)
Your opponents can't block with creatures with even mana values.

Loyal Subordinate

Menace (This creature can't be blocked except by two or more creatures.)
Lieutenant — At the beginning of combat on your turn, if you control your commander, each opponent loses 3 life.

Ugin's Nexus

If a player would begin an extra turn, that player skips that turn instead.
If Ugin's Nexus would be put into a graveyard from the battlefield, instead exile it and take an extra turn after this one.

Swift End

Destroy target creature or planeswalker. You lose 2 life. (Then exile this card. You may cast the creature later from exile.)

Murderous Rider

Lifelink
When Murderous Rider dies, put it on the bottom of its owner's library.

Murderous Rider // Swift End

Nature's Claim

Destroy target artifact or enchantment. Its controller gains 4 life.

Mikaeus, the Unhallowed

Intimidate (This creature can't be blocked except by artifact creatures and/or creatures that share a color with it.)
Whenever a Human deals damage to you, destroy it.
Other non-Human creatures you control get +1/+1 and have undying. (When a creature with undying dies, if it had no +1/+1 counters on it, return it to the battlefield under its owner's control with a +1/+1 counter on it.)

Warping Wail

({C} represents colorless mana.)
Choose one —
• Exile target creature with power or toughness 1 or less.
• Counter target sorcery spell.
• Create a 1/1 colorless Eldrazi Scion creature token. It has "Sacrifice this creature: Add {C}."

Elves of Deep Shadow

{T}: Add {B}. Elves of Deep Shadow deals 1 damage to you.

Price of Knowledge

Players have no maximum hand size.
At the beginning of each opponent's upkeep, Price of Knowledge deals damage to that player equal to the number of cards in that player's hand.

Deadly Rollick

If you control a commander, you may cast this spell without paying its mana cost.
Exile target creature.

Infernal Reckoning

Exile target colorless creature. You gain life equal to its power.

Shepherd of Rot

{T}: Each player loses 1 life for each Zombie on the battlefield.

Night Market Lookout

Whenever Night Market Lookout becomes tapped, each opponent loses 1 life and you gain 1 life.

Oakhame Adversary

This spell costs {2} less to cast if an opponent controls a green permanent.
Deathtouch
Whenever Oakhame Adversary deals combat damage to a player, draw a card.

Karn, Scion of Urza

+1: Reveal the top two cards of your library. An opponent chooses one of them. Put that card into your hand and exile the other with a silver counter on it.
−1: Put a card you own with a silver counter on it from exile into your hand.
−2: Create a 0/0 colorless Construct artifact creature token with "This creature gets +1/+1 for each artifact you control."

Sphere of Resistance

Carpet of Flowers

At the beginning of each of your main phases, if you haven't added mana with this ability this turn, you may add X mana of any one color, where X is the number of Islands target opponent controls.

Mardu Shadowspear

Whenever Mardu Shadowspear attacks, each opponent loses 1 life.
Dash {1}{B} (You may cast this spell for its dash cost. If you do, it gains haste, and it's returned from the battlefield to its owner's hand at the beginning of the next end step.)

Retreat to Hagra

Landfall — Whenever a land you control enters, choose one —
• Target creature gets +1/+0 and gains deathtouch until end of turn.
• Each opponent loses 1 life and you gain 1 life.

Vicious Conquistador

Whenever Vicious Conquistador attacks, each opponent loses 1 life.

Stunning Reversal

The next time you would lose the game this turn, instead draw seven cards and your life total becomes 1.
Exile Stunning Reversal.

Elvish Mystic

Thornbow Archer

Whenever Thornbow Archer attacks, each opponent who doesn't control an Elf loses 1 life.

Archfiend of Despair

Flying
Your opponents can't gain life.
At the beginning of each end step, each opponent loses life equal to the life that player lost this turn. (Damage causes loss of life.)

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Witch of the Moors

Deathtouch
At the beginning of your end step, if you gained life this turn, each opponent sacrifices a creature and you return up to one target creature card from your graveyard to your hand.

Return to Nature

Choose one —
• Destroy target artifact.
• Destroy target enchantment.
• Exile target card from a graveyard.

Ohran Frostfang

Attacking creatures you control have deathtouch.
Whenever a creature you control deals combat damage to a player, draw a card.

Thorn of Amethyst

Noncreature spells cost {1} more to cast.

Mire in Misery

Each opponent sacrifices a creature or enchantment.

Palace Siege

As Palace Siege enters, choose Khans or Dragons.
• Khans — At the beginning of your upkeep, return target creature card from your graveyard to your hand.
• Dragons — At the beginning of your upkeep, each opponent loses 2 life and you gain 2 life.

Doom Blade

Belbe, Corrupted Observer

At the beginning of each postcombat main phase, the active player adds {C}{C} for each of your opponents who lost life this turn. (Damage causes loss of life.)

Cling to Dust

Exile target card from a graveyard. If it was a creature card, you gain 3 life. Otherwise, you draw a card.
Escape—{3}{B}, Exile five other cards from your graveyard. (You may cast this card from your graveyard for its escape cost.)

Court of Ambition

When Court of Ambition enters, you become the monarch.
At the beginning of your upkeep, each opponent loses 3 life unless they discard a card. If you're the monarch, instead each opponent loses 6 life unless they discard two cards.

Tribute to the Wild

Each opponent sacrifices an artifact or enchantment.

Assassin's Trophy

Destroy target permanent an opponent controls. Its controller may search their library for a basic land card, put it onto the battlefield, then shuffle.

Opposition Agent

Flash
You control your opponents while they're searching their libraries.
While an opponent is searching their library, they exile each card they find. You may play those cards for as long as they remain exiled, and you may spend mana as though it were mana of any color to cast them.

Tormod's Crypt

{T}, Sacrifice Tormod's Crypt: Exile target player's graveyard.

Natural State

Destroy target artifact or enchantment with mana value 3 or less.

Eliminate

Destroy target creature or planeswalker with mana value 3 or less.

Liliana's Triumph

Each opponent sacrifices a creature. If you control a Liliana planeswalker, each opponent also discards a card.

Twilight Prophet

Flying
Ascend (If you control ten or more permanents, you get the city's blessing for the rest of the game.)
At the beginning of your upkeep, if you have the city's blessing, reveal the top card of your library and put it into your hand. Each opponent loses X life and you gain X life, where X is that card's mana value.