Let the Galaxy Burn

Cascade (When you cast this spell, exile cards from the top of your library until you exile a nonland card that costs less. You may cast it without paying its mana cost. Put the exiled cards on the bottom in a random order.)
Let the Galaxy Burn deals X plus 2 damage to each creature that didn't enter this turn.

Mogg Infestation

Destroy all creatures target player controls. For each creature that died this way, that player creates two 1/1 red Goblin creature tokens.

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.

Time Wipe

Return a creature you control to its owner's hand, then destroy all creatures.

Kederekt Leviathan

When Kederekt Leviathan enters, return all other nonland permanents to their owners' hands.
Unearth {6}{U} ({6}{U}: Return this card from your graveyard to the battlefield. It gains haste. Exile it at the beginning of the next end step or if it would leave the battlefield. Unearth only as a sorcery.)

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Earth

Aftermath (Cast this spell only from your graveyard. Then exile it.)
Earth deals X damage to each creature without flying.

Heaven

Heaven deals X damage to each creature with flying.

Heaven // Earth

Aetherize

Return all attacking creatures to their owner's hand.

Child of Alara

Trample
When Child of Alara dies, destroy all nonland permanents. They can't be regenerated.

Rolling Earthquake

Rolling Earthquake deals X damage to each creature without horsemanship and each player.

Kaya's Wrath

Destroy all creatures. You gain life equal to the number of creatures you controlled that were destroyed this way.

Martial Coup

Create X 1/1 white Soldier creature tokens. If X is 5 or more, destroy all other creatures.

Phyrexian Rebirth

Destroy all creatures, then create an X/X colorless Phyrexian Horror artifact creature token, where X is the number of creatures destroyed this way.

Worldpurge

Return all permanents to their owners' hands. Each player chooses up to seven cards in their hand, then shuffles the rest into their library. Each player loses all unspent mana.

Displacement Wave

Return all nonland permanents with mana value X or less to their owners' hands.

Plague Boiler

At the beginning of your upkeep, put a plague counter on Plague Boiler.
{1}{B}{G}: Put a plague counter on Plague Boiler or remove a plague counter from it.
When Plague Boiler has three or more plague counters on it, sacrifice it. If you do, destroy all nonland permanents.

Cast Off

Destroy all non-Giant creatures. (Then exile this card. You may cast the creature later from exile.)

Realm-Cloaked Giant

Realm-Cloaked Giant // Cast Off

Evacuation

Return all creatures to their owners' hands.

Crisis of Conscience

Choose one —
• Destroy all tokens.
• Destroy all nonland, nontoken permanents.

Engulf the Shore

Return to their owners' hands all creatures with toughness less than or equal to the number of Islands you control.

Kindred Dominance

Choose a creature type. Destroy all creatures that aren't of the chosen type.

Day of Judgment

Paraselene

Destroy all enchantments. You gain 1 life for each enchantment destroyed this way.

Starfall Invocation

Gift a card (You may promise an opponent a gift as you cast this spell. If you do, they draw a card before its other effects.)
Destroy all creatures. If the gift was promised, return a creature card put into your graveyard this way to the battlefield under your control.

All Is Dust

Each player sacrifices all permanents they control that are one or more colors.

Vanquish the Horde

This spell costs {1} less to cast for each creature on the battlefield.
Destroy all creatures.

Slash the Ranks

Destroy all creatures and planeswalkers except for commanders.

Filter Out

Return all noncreature, nonland permanents to their owners' hands.

Phyrexian Scriptures

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — Put a +1/+1 counter on up to one target creature. That creature becomes an artifact in addition to its other types.
II — Destroy all nonartifact creatures.
III — Exile all opponents' graveyards.

Hour of Revelation

This spell costs {3} less to cast if there are ten or more nonland permanents on the battlefield.
Destroy all nonland permanents.

Oblivion Stone

{4}, {T}: Put a fate counter on target permanent.
{5}, {T}, Sacrifice Oblivion Stone: Destroy each nonland permanent without a fate counter on it, then remove all fate counters from all permanents.

Rupture

Sacrifice a creature. Rupture deals damage equal to that creature's power to each creature without flying and each player.

Merciless Eviction

Choose one —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all planeswalkers.

Delete

Delete deals X damage to each nonartifact creature and each player.

Path of Peril

Cleave {4}{W}{B} (You may cast this spell for its cleave cost. If you do, remove the words in square brackets.)
Destroy all creatures [with mana value 2 or less].

Fell the Mighty

Destroy all creatures with power greater than target creature's power.

In Garruk's Wake

Destroy all creatures you don't control and all planeswalkers you don't control.

Ryusei, the Falling Star

Flying
When Ryusei, the Falling Star dies, it deals 5 damage to each creature without flying.

Cataclysmic Prospecting

Cataclysmic Prospecting deals X damage to each creature. For each mana from a Desert spent to cast this spell, create a tapped Treasure token.

Their Name Is Death

Calamity of Cinders

Convoke (Your creatures can help cast this spell. Each creature you tap while casting this spell pays for {1} or one mana of that creature's color.)
Calamity of Cinders deals 6 damage to each untapped creature.

Chandra's Ignition

Target creature you control deals damage equal to its power to each other creature and each opponent.

Coastal Breach

Undaunted (This spell costs {1} less to cast for each opponent.)
Return all nonland permanents to their owners' hands.

Cyclonic Rift

Return target nonland permanent you don't control to its owner's hand.
Overload {6}{U} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Blasphemous Act

This spell costs {1} less to cast for each creature on the battlefield.
Blasphemous Act deals 13 damage to each creature.

Hour of Devastation

All creatures lose indestructible until end of turn. Hour of Devastation deals 5 damage to each creature and each non-Bolas planeswalker.

Blood on the Snow

Choose one —
• Destroy all creatures.
• Destroy all planeswalkers.
Then return a creature or planeswalker card with mana value X or less from your graveyard to the battlefield, where X is the amount of {S} spent to cast this spell. ({S} is mana from a snow source.)

Farewell

Choose one or more —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all graveyards.

Doomskar

Destroy all creatures.
Foretell {1}{W}{W} (During your turn, you may pay {2} and exile this card from your hand face down. Cast it on a later turn for its foretell cost.)

Widespread Brutality

Amass Zombies 2, then the Army you amassed deals damage equal to its power to each non-Army creature. (To amass Zombies 2, put two +1/+1 counters on an Army you control. It's also a Zombie. If you don't control an Army, create a 0/0 black Zombie Army creature token first.)

Rout

You may cast Rout as though it had flash if you pay {2} more to cast it. (You may cast it any time you could cast an instant.)
Destroy all creatures. They can't be regenerated.

Winds of Rath

Destroy all creatures that aren't enchanted. They can't be regenerated.

Wakening Sun's Avatar

When Wakening Sun's Avatar enters, if you cast it from your hand, destroy all non-Dinosaur creatures.

Sublime Exhalation

Undaunted (This spell costs {1} less to cast for each opponent.)
Destroy all creatures.

Savage Twister

Savage Twister deals X damage to each creature.

Iridian Maelstrom

Destroy each creature that isn't all colors.

Rampage of the Clans

Destroy all artifacts and enchantments. For each permanent destroyed this way, its controller creates a 3/3 green Centaur creature token.

Planar Outburst

Destroy all nonland creatures.
Awaken 4—{5}{W}{W}{W} (If you cast this spell for {5}{W}{W}{W}, also put four +1/+1 counters on target land you control and it becomes a 0/0 Elemental creature with haste. It's still a land.)

Chain Reaction

Chain Reaction deals X damage to each creature, where X is the number of creatures on the battlefield.

Whelming Wave

Return all creatures to their owners' hands except for Krakens, Leviathans, Octopuses, and Serpents.

Supreme Verdict

This spell can't be countered.
Destroy all creatures.

Bane of Progress

When Bane of Progress enters, destroy all artifacts and enchantments. Put a +1/+1 counter on Bane of Progress for each permanent destroyed this way.

Earthquake

Earthquake deals X damage to each creature without flying and each player.

Devastation Tide

Return all nonland permanents to their owners' hands.
Miracle {1}{U} (You may cast this card for its miracle cost when you draw it if it's the first card you drew this turn.)

River's Rebuke

Return all nonland permanents target player controls to their owner's hand.

Shatter the Sky

Each player who controls a creature with power 4 or greater draws a card. Then destroy all creatures.

Burn Down the House

Choose one —
• Burn Down the House deals 5 damage to each creature and each planeswalker.
• Create three 1/1 red Devil creature tokens with "When this creature dies, it deals 1 damage to any target." They gain haste until end of turn.

March of Souls

Destroy all creatures. They can't be regenerated. For each creature destroyed this way, its controller creates a 1/1 white Spirit creature token with flying.

Ruinous Ultimatum

Destroy all nonland permanents your opponents control.

Star of Extinction

Destroy target land. Star of Extinction deals 20 damage to each creature and each planeswalker.

Dawn

Aftermath (Cast this spell only from your graveyard. Then exile it.)
Return all creature cards with power 2 or less from your graveyard to your hand.

Dusk

Destroy all creatures with power 3 or greater.

Dusk // Dawn

Exterminatus

Nonland permanents your opponents control lose indestructible until end of turn.
Destroy all nonland permanents.

Scalding Salamander

Whenever Scalding Salamander attacks, you may have it deal 1 damage to each creature without flying defending player controls.

Aligned Hedron Network

When Aligned Hedron Network enters, exile all creatures with power 5 or greater until Aligned Hedron Network leaves the battlefield. (Those creatures return under their owners' control.)

Myojin of Cleansing Fire

Myojin of Cleansing Fire enters with a divinity counter on it if you cast it from your hand.
Myojin of Cleansing Fire has indestructible as long as it has a divinity counter on it.
Remove a divinity counter from Myojin of Cleansing Fire: Destroy all other creatures.

Back to Nature

Damnation

Destroy all creatures. They can't be regenerated.

Nevinyrral's Disk

Nevinyrral's Disk enters tapped.
{1}, {T}: Destroy all artifacts, creatures, and enchantments.

Subterranean Tremors

Subterranean Tremors deals X damage to each creature without flying. If X is 4 or more, destroy all artifacts. If X is 8 or more, create an 8/8 red Lizard creature token.

Final Act

Choose one or more —
• Destroy all creatures.
• Destroy all planeswalkers.
• Destroy all battles.
• Exile all graveyards.
• Each opponent loses all counters.