Sulfuric Vortex

At the beginning of each player's upkeep, Sulfuric Vortex deals 2 damage to that player.
If a player would gain life, that player gains no life instead.

Persistent Constrictor

At the beginning of each opponent's upkeep, they lose 1 life and you put a -1/-1 counter on up to one target creature they control.
Persist (When this creature dies, if it had no -1/-1 counters on it, return it to the battlefield under its owner's control with a -1/-1 counter on it.)

Manabarbs

Whenever a player taps a land for mana, Manabarbs deals 1 damage to that player.

Light Up the Stage

Spectacle {R} (You may cast this spell for its spectacle cost rather than its mana cost if an opponent lost life this turn.)
Exile the top two cards of your library. Until the end of your next turn, you may play those cards.

Roiling Vortex

At the beginning of each player's upkeep, Roiling Vortex deals 1 damage to them.
Whenever a player casts a spell, if no mana was spent to cast that spell, Roiling Vortex deals 5 damage to that player.
{R}: Your opponents can't gain life this turn.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Solemn Simulacrum

When Solemn Simulacrum enters, you may search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.
When Solemn Simulacrum dies, you may draw a card.

Valgavoth, Harrower of Souls

Flying
Ward—Pay 2 life.
Whenever an opponent loses life for the first time during each of their turns, put a +1/+1 counter on Valgavoth, Harrower of Souls and draw a card.

Fate Unraveler

Whenever an opponent draws a card, Fate Unraveler deals 1 damage to that player.

Ob Nixilis, Captive Kingpin

Flying, trample
Whenever one or more opponents each lose exactly 1 life, put a +1/+1 counter on Ob Nixilis, Captive Kingpin. Exile the top card of your library. Until your next end step, you may play that card.

Vandalblast

Destroy target artifact you don't control.
Overload {4}{R} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Razorkin Needlehead

Razorkin Needlehead has first strike during your turn.
Whenever an opponent draws a card, Razorkin Needlehead deals 1 damage to them.

Harsh Mentor

Whenever an opponent activates an ability of an artifact, creature, or land on the battlefield, if it isn't a mana ability, Harsh Mentor deals 2 damage to that player.

Chandra, Awakened Inferno

This spell can't be countered.
+2: Each opponent gets an emblem with "At the beginning of your upkeep, this emblem deals 1 damage to you."
−3: Chandra, Awakened Inferno deals 3 damage to each non-Elemental creature.
−X: Chandra, Awakened Inferno deals X damage to target creature or planeswalker. If a permanent dealt damage this way would die this turn, exile it instead.

Lightning Greaves

Equipped creature has haste and shroud. (It can't be the target of spells or abilities.)
Equip {0}

Vial Smasher the Fierce

Whenever you cast your first spell each turn, choose an opponent at random. Vial Smasher the Fierce deals damage equal to that spell's mana value to that player or a planeswalker that player controls.
Partner (You can have two commanders if both have partner.)

Kardur, Doomscourge

When Kardur, Doomscourge enters, until your next turn, creatures your opponents control attack each combat if able and attack a player other than you if able.
Whenever an attacking creature dies, each opponent loses 1 life and you gain 1 life.

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Descent into Avernus

At the beginning of your upkeep, put two descent counters on Descent into Avernus. Then each player creates X Treasure tokens and Descent into Avernus deals X damage to each player, where X is the number of descent counters on Descent into Avernus.

Temple of Malice

Temple of Malice enters tapped.
When Temple of Malice enters, scry 1.
{T}: Add {B} or {R}.

Orcish Bowmasters

Flash
When Orcish Bowmasters enters and whenever an opponent draws a card except the first one they draw in each of their draw steps, Orcish Bowmasters deals 1 damage to any target. Then amass Orcs 1.

Rug of Smothering

Flying
Whenever a player casts a spell, they lose 1 life for each spell they've cast this turn.

Rakdos Signet

Tibalt's Trickery

Counter target spell. Choose 1, 2, or 3 at random. Its controller mills that many cards, then exiles cards from the top of their library until they exile a nonland card with a different name than that spell. They may cast that card without paying its mana cost. Then they put the exiled cards on the bottom of their library in a random order.

Zo-Zu the Punisher

Whenever a land enters, Zo-Zu the Punisher deals 2 damage to that land's controller.

Bojuka Bog

Bojuka Bog enters tapped.
When Bojuka Bog enters, exile target player's graveyard.
{T}: Add {B}.

Grab the Prize

As an additional cost to cast this spell, discard a card.
Draw two cards. If the discarded card wasn't a land card, Grab the Prize deals 2 damage to each opponent.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Foreboding Ruins

As Foreboding Ruins enters, you may reveal a Swamp or Mountain card from your hand. If you don't, Foreboding Ruins enters tapped.
{T}: Add {B} or {R}.

Blood Artist

Whenever Blood Artist or another creature dies, target player loses 1 life and you gain 1 life.

Gleeful Arsonist

Whenever an opponent casts a noncreature spell, Gleeful Arsonist deals damage equal to its power to that player.
Undying (When this creature dies, if it had no +1/+1 counters on it, return it to the battlefield under its owner's control with a +1/+1 counter on it.)

Solphim, Mayhem Dominus

If a source you control would deal noncombat damage to an opponent or a permanent an opponent controls, it deals double that damage to that player or permanent instead.
{1}{R/P}{R/P}, Discard two cards: Put an indestructible counter on Solphim, Mayhem Dominus. ({R/P} can be paid with either {R} or 2 life.)

Dark Ritual

Kaervek the Merciless

Whenever an opponent casts a spell, Kaervek the Merciless deals damage equal to that spell's mana value to any target.

Rampaging Ferocidon

Menace
Players can't gain life.
Whenever another creature enters, Rampaging Ferocidon deals 1 damage to that creature's controller.

Mogis, God of Slaughter

Indestructible
As long as your devotion to black and red is less than seven, Mogis isn't a creature.
At the beginning of each opponent's upkeep, Mogis deals 2 damage to that player unless they sacrifice a creature of their choice.

Blood Seeker

Whenever a creature an opponent controls enters, you may have that player lose 1 life.

Chaos Warp

The owner of target permanent shuffles it into their library, then reveals the top card of their library. If it's a permanent card, they put it onto the battlefield.

Sadistic Shell Game

Starting with the next opponent in turn order, each player chooses a creature you don't control. Destroy the chosen creatures.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Blood Crypt

({T}: Add {B} or {R}.)
As Blood Crypt enters, you may pay 2 life. If you don't, it enters tapped.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Jeska's Will

Choose one. If you control a commander as you cast this spell, you may choose both instead.
• Add {R} for each card in target opponent's hand.
• Exile the top three cards of your library. You may play them this turn.

Sol Ring

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Fear of Burning Alive

When Fear of Burning Alive enters, it deals 4 damage to each opponent.
Delirium — Whenever a source you control deals noncombat damage to an opponent, if there are four or more card types among cards in your graveyard, Fear of Burning Alive deals that amount of damage to target creature that player controls.

Blasphemous Act

This spell costs {1} less to cast for each creature on the battlefield.
Blasphemous Act deals 13 damage to each creature.

Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on Bloodchief Ascension. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if Bloodchief Ascension has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Untimely Malfunction

Choose one —
• Destroy target artifact.
• Change the target of target spell or ability with a single target.
• One or two target creatures can't block this turn.

The Lord of Pain

Menace
Your opponents can't gain life.
Whenever a player casts their first spell each turn, choose another target player. The Lord of Pain deals damage equal to that spell's mana value to the chosen player.

Infernal Grasp

Destroy target creature. You lose 2 life.

Rakdos Charm

Choose one —
• Exile target player's graveyard.
• Destroy target artifact.
• Each creature deals 1 damage to its controller.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control.)
Equip {1}

Mount Doom

{T}, Pay 1 life: Add {B} or {R}.
{1}{B}{R}, {T}: Mount Doom deals 1 damage to each opponent.
{5}{B}{R}, {T}, Sacrifice Mount Doom and a legendary artifact: Choose up to two creatures, then destroy the rest. Activate only as a sorcery.

Talisman of Indulgence

{T}: Add {C}.
{T}: Add {B} or {R}. Talisman of Indulgence deals 1 damage to you.

Magebane Lizard

Whenever a player casts a noncreature spell, Magebane Lizard deals damage to that player equal to the number of noncreature spells they've cast this turn.

Kederekt Parasite

Whenever an opponent draws a card, if you control a red permanent, you may have Kederekt Parasite deal 1 damage to that player.

Rakdos Carnarium

Rakdos Carnarium enters tapped.
When Rakdos Carnarium enters, return a land you control to its owner's hand.
{T}: Add {B}{R}.

Arcane Signet

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Reanimate

Put target creature card from a graveyard onto the battlefield under your control. You lose life equal to its mana value.