Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Cruel Bargain

Draw four cards. You lose half your life, rounded up.

Charcoal Diamond

This artifact enters tapped.
{T}: Add {B}.

Liability

Whenever a nontoken permanent is put into a player's graveyard from the battlefield, that player loses 1 life.

Necropotence

Skip your draw step.
Whenever you discard a card, exile that card from your graveyard.
Pay 1 life: Exile the top card of your library face down. Put that card into your hand at the beginning of your next end step.

Maggot Carrier

When this creature enters, each player loses 1 life.

Greed

Foul Imp

Flying
When this creature enters, you lose 2 life.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Ancient Tomb

{T}: Add {C}{C}. This land deals 2 damage to you.

Verdant Catacombs

{T}, Pay 1 life, Sacrifice this land: Search your library for a Swamp or Forest card, put it onto the battlefield, then shuffle.

Feed the Infection

You draw three cards and you lose 3 life.
Corrupted — Each opponent who has three or more poison counters loses 3 life.

Blood Pact

Target player draws two cards and loses 2 life.

Ambition's Cost

You draw three cards and you lose 3 life.

Agadeem, the Undercrypt

As this land enters, you may pay 3 life. If you don't, it enters tapped.
{T}: Add {B}.

Agadeem's Awakening

Return from your graveyard to the battlefield any number of target creature cards that each have a different mana value X or less.

Agadeem's Awakening // Agadeem, the Undercrypt

Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Wanderer's Twig

{1}, Sacrifice this artifact: Search your library for a basic land card, reveal it, put it into your hand, then shuffle.

Bitterblossom

At the beginning of your upkeep, you lose 1 life and create a 1/1 black Faerie Rogue creature token with flying.

Vampiric Tutor

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Howling Mine

At the beginning of each player's draw step, if this artifact is untapped, that player draws an additional card.

Grim Tutor

Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice this artifact: Draw a card.

Staff of Compleation

{T}, Pay 1 life: Destroy target permanent you own.
{T}, Pay 2 life: Add one mana of any color.
{T}, Pay 3 life: Proliferate.
{T}, Pay 4 life: Draw a card.
{5}: Untap this artifact.

Foreboding Fruit

Target player draws two cards and loses 2 life.
Adamant — If at least three black mana was spent to cast this spell, create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this token: You gain 3 life.")

Liliana's Contract

When this enchantment enters, you draw four cards and you lose 4 life.
At the beginning of your upkeep, if you control four or more Demons with different names, you win the game.

Eye of Vecna

When Eye of Vecna enters, you draw a card and you lose 2 life.
At the beginning of your upkeep, you may pay {2}. If you do, you draw a card and you lose 2 life.

Polluted Delta

{T}, Pay 1 life, Sacrifice this land: Search your library for an Island or Swamp card, put it onto the battlefield, then shuffle.

Swamp

Horn of Greed

Whenever a player plays a land, that player draws a card.

Sol Ring

The Black Gate

As The Black Gate enters, you may pay 3 life. If you don't, it enters tapped.
{T}: Add {B}.
{1}{B}, {T}: Choose a player with the most life or tied for most life. Target creature can't be blocked by creatures that player controls this turn.

Imperial Seal

Dark Ritual

Glacial Chasm

Cumulative upkeep—Pay 2 life. (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)
When this land enters, sacrifice a land.
Creatures you control can't attack.
Prevent all damage that would be dealt to you.

Demonic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Thought Vessel

You have no maximum hand size.
{T}: Add {C}.

Bitter Triumph

As an additional cost to cast this spell, discard a card or pay 3 life.
Destroy target creature or planeswalker.

Prismatic Vista

{T}, Pay 1 life, Sacrifice this land: Search your library for a basic land card, put it onto the battlefield, then shuffle.

Liquimetal Torque

{T}: Add {C}.
{T}: Target nonland permanent becomes an artifact in addition to its other types until end of turn.

Piranha Marsh

This land enters tapped.
When this land enters, target player loses 1 life.
{T}: Add {B}.

Marsh Flats

{T}, Pay 1 life, Sacrifice this land: Search your library for a Plains or Swamp card, put it onto the battlefield, then shuffle.

Darkstar Augur

Offspring {B} (You may pay an additional {B} as you cast this spell. If you do, when this creature enters, create a 1/1 token copy of it.)
Flying
At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Murderous Betrayal

{B}{B}, Pay half your life, rounded up: Destroy target nonblack creature. It can't be regenerated.

Demonic Lore

When this enchantment enters, draw three cards.
At the beginning of your end step, you lose 2 life for each card in your hand.

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Wayfarer's Bauble

{2}, {T}, Sacrifice this artifact: Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Phyrexian Processor

As this artifact enters, pay any amount of life.
{4}, {T}: Create an X/X black Phyrexian Minion creature token, where X is the life paid as this artifact entered.

Necrodominance

Skip your draw step.
At the beginning of your end step, you may pay any amount of life. If you do, draw that many cards.
Your maximum hand size is five.
If a card or token would be put into your graveyard from anywhere, exile it instead.

Bloodstained Mire

{T}, Pay 1 life, Sacrifice this land: Search your library for a Swamp or Mountain card, put it onto the battlefield, then shuffle.

Nocturnal Hunger

Gift a Food (You may promise an opponent a gift as you cast this spell. If you do, they create a Food token before its other effects. It's an artifact with "{2}, {T}, Sacrifice this token: You gain 3 life.")
Destroy target creature. If the gift wasn't promised, you lose 2 life.

Boggart Bog

Boggart Trawler

When this creature enters, exile target player's graveyard.

Boggart Trawler // Boggart Bog

Infernal Grasp

Destroy target creature. You lose 2 life.

Mox Diamond

If this artifact would enter, you may discard a land card instead. If you do, put this artifact onto the battlefield. If you don't, put it into its owner's graveyard.
{T}: Add one mana of any color.

Swift End

Destroy target creature or planeswalker. You lose 2 life. (Then exile this card. You may cast the creature later from exile.)

Murderous Rider

Lifelink
When this creature dies, put it on the bottom of its owner's library.

Murderous Rider // Swift End

Night's Whisper

Ifnir Deadlands

{T}: Add {C}.
{T}, Pay 1 life: Add {B}.
{2}{B}{B}, {T}, Sacrifice a Desert: Put two -1/-1 counters on target creature an opponent controls. Activate only as a sorcery.

Untaidake, the Cloud Keeper

Untaidake enters tapped.
{T}, Pay 2 life: Add {C}{C}. Spend this mana only to cast legendary spells.

Ancient Craving

Sign in Blood

Traveler's Amulet

Voldaren Estate

{T}: Add {C}.
{T}, Pay 1 life: Add one mana of any color. Spend this mana only to cast a Vampire spell.
{5}, {T}: Create a Blood token. This ability costs {1} less to activate for each Vampire you control. (It's an artifact with "{1}, {T}, Discard a card, Sacrifice this token: Draw a card.")

Dark Confidant

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Fractured Powerstone

{T}: Add {C}.
{T}: Roll the planar die. Activate only as a sorcery.

Blood Celebrant

{B}, Pay 1 life: Add one mana of any color.

Prismatic Lens

{T}: Add {C}.
{1}, {T}: Add one mana of any color.

Infernal Contract

Carrion Howler

Pay 1 life: This creature gets +2/-1 until end of turn.

Cruel Tutor

Mox Opal

Metalcraft — {T}: Add one mana of any color. Activate only if you control three or more artifacts.

Black Market Connections

At the beginning of your first main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It is every creature type.)

Live Fast

You draw two cards, lose 2 life, and get {E}{E} (two energy counters).

Fell Mire

Fell the Profane

Fell the Profane // Fell Mire

Temple of Aclazotz

(Transforms from Arguel's Blood Fast.)
{T}: Add {B}.
{T}, Sacrifice a creature: You gain life equal to the sacrificed creature's toughness.

Arguel's Blood Fast

{1}{B}, Pay 2 life: Draw a card.
At the beginning of your upkeep, if you have 5 or less life, you may transform Arguel's Blood Fast.

Arguel's Blood Fast // Temple of Aclazotz

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Mana Confluence

{T}, Pay 1 life: Add one mana of any color.

City of Brass

Whenever this land becomes tapped, it deals 1 damage to you.
{T}: Add one mana of any color.

Lurking Evil

Pay half your life, rounded up: This enchantment becomes a 4/4 Phyrexian Horror creature with flying.

Hall of the Bandit Lord

Hall of the Bandit Lord enters tapped.
{T}, Pay 3 life: Add {C}. If that mana is spent on a creature spell, it gains haste.

Gruesome Realization

Choose one —
• You draw two cards and you lose 2 life.
• Creatures your opponents control get -1/-1 until end of turn.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

The Irencrag

{T}: Add {C}.
Whenever a legendary creature you control enters, you may have The Irencrag become a legendary Equipment artifact named Everflame, Heroes' Legacy. If you do, it gains equip {3} and "Equipped creature gets +3/+3" and loses all other abilities.

Dystopia

Cumulative upkeep—Pay 1 life. (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)
At the beginning of each player's upkeep, that player sacrifices a green or white permanent of their choice.