Splendid Agony

Distribute two -1/-1 counters among one or two target creatures.

Massacre Girl, Known Killer

Menace
Creatures you control have wither. (They deal damage to creatures in the form of -1/-1 counters.)
Whenever a creature an opponent controls dies, if its toughness was less than 1, draw a card.

Tymaret, Chosen from Death

Tymaret's toughness is equal to your devotion to black. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)
{1}{B}: Exile up to two target cards from graveyards. You gain 1 life for each creature card exiled this way.

Swamp

Suffocating Fumes

Creatures your opponents control get -1/-1 until end of turn.
Cycling {2} ({2}, Discard this card: Draw a card.)

Stargaze

Look at twice X cards from the top of your library. Put X cards from among them into your hand and the rest into your graveyard. You lose X life.

Spread the Sickness

Destroy target creature, then proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Nykthos, Shrine to Nyx

{T}: Add {C}.
{2}, {T}: Choose a color. Add an amount of mana of that color equal to your devotion to that color. (Your devotion to a color is the number of mana symbols of that color in the mana costs of permanents you control.)

Ichorclaw Myr

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
Whenever Ichorclaw Myr becomes blocked, it gets +2/+2 until end of turn.

Drown in Ichor

Target creature gets -4/-4 until end of turn. Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Liliana of the Dark Realms

+1: Search your library for a Swamp card, reveal it, put it into your hand, then shuffle.
−3: Target creature gets +X/+X or -X/-X until end of turn, where X is the number of Swamps you control.
−6: You get an emblem with "Swamps you control have '{T}: Add {B}{B}{B}{B}.'"

Hand of the Praetors

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
Other creatures you control with infect get +1/+1.
Whenever you cast a creature spell with infect, target player gets a poison counter.

Scheming Aspirant

Whenever you proliferate, each opponent loses 2 life and you gain 2 life.

Virulent Wound

Put a -1/-1 counter on target creature. When that creature dies this turn, its controller gets a poison counter.

Phyrexian Juggernaut

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
Phyrexian Juggernaut attacks each combat if able.

Heraldic Banner

As this artifact enters, choose a color.
Creatures you control of the chosen color get +1/+0.
{T}: Add one mana of the chosen color.

Reassembling Skeleton

{1}{B}: Return this card from your graveyard to the battlefield tapped.

Tocasia's Dig Site

{T}: Add {C}.
{3}, {T}: Surveil 1. (Look at the top card of your library. You may put it into your graveyard.)

Whisper of the Dross

Target creature gets -1/-1 until end of turn. Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Vraska's Fall

Each opponent sacrifices a creature or planeswalker of their choice and gets a poison counter.

Pith Driller

({B/P} can be paid with either {B} or 2 life.)
When Pith Driller enters, put a -1/-1 counter on target creature.

Blighted Fen

{T}: Add {C}.
{4}{B}, {T}, Sacrifice Blighted Fen: Target opponent sacrifices a creature of their choice.

Reaper of Sheoldred

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
Whenever a source deals damage to Reaper of Sheoldred, that source's controller gets a poison counter.

Pharika's Cure

Pharika's Cure deals 2 damage to target creature and you gain 2 life.

Phyrexian Digester

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)

Flensermite

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)

Myriad Landscape

Myriad Landscape enters tapped.
{T}: Add {C}.
{2}, {T}, Sacrifice Myriad Landscape: Search your library for up to two basic land cards that share a land type, put them onto the battlefield tapped, then shuffle.

Fungal Infection

Target creature gets -1/-1 until end of turn. Create a 1/1 green Saproling creature token.

K'rrik, Son of Yawgmoth

({B/P} can be paid with either {B} or 2 life.)
Lifelink
For each {B} in a cost, you may pay 2 life rather than pay that mana.
Whenever you cast a black spell, put a +1/+1 counter on K'rrik, Son of Yawgmoth.

Plague Stinger

Flying
Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)

Clawing Torment

Enchant artifact or creature
As long as enchanted permanent is a creature, it gets -1/-1 and can't block.
Enchanted permanent has "At the beginning of your upkeep, you lose 1 life."

Barren Moor

Barren Moor enters tapped.
{T}: Add {B}.
Cycling {B} ({B}, Discard this card: Draw a card.)

Contagious Nim

Field of Ruin

{T}: Add {C}.
{2}, {T}, Sacrifice Field of Ruin: Destroy target nonbasic land an opponent controls. Each player searches their library for a basic land card, puts it onto the battlefield, then shuffles.

Skithiryx, the Blight Dragon

Flying
Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
{B}: Skithiryx, the Blight Dragon gains haste until end of turn.
{B}{B}: Regenerate Skithiryx.

Toxic Nim

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
{B}: Regenerate Toxic Nim.

Unknown Shores

{T}: Add {C}.
{1}, {T}: Add one mana of any color.

Path of Ancestry

Path of Ancestry enters tapped.
{T}: Add one mana of any color in your commander's color identity. When that mana is spent to cast a creature spell that shares a creature type with your commander, scry 1. (Look at the top card of your library. You may put that card on the bottom.)

Scourge Servant

Skinrender

When Skinrender enters, put three -1/-1 counters on target creature.

Stabbing Pain

Target creature gets -1/-1 until end of turn. Tap that creature.

Grim Affliction

Put a -1/-1 counter on target creature, then proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Falkenrath Noble

Flying
Whenever Falkenrath Noble or another creature dies, target player loses 1 life and you gain 1 life.

Talon of Pain

Whenever a source you control other than Talon of Pain deals damage to an opponent, put a charge counter on Talon of Pain.
{X}, {T}, Remove X charge counters from Talon of Pain: It deals X damage to any target.

Demolition Field

{T}: Add {C}.
{2}, {T}, Sacrifice this land: Destroy target nonbasic land an opponent controls. That land's controller may search their library for a basic land card, put it onto the battlefield, then shuffle. You may search your library for a basic land card, put it onto the battlefield, then shuffle.