The Mightstone and Weakstone

When The Mightstone and Weakstone enters, choose one —
• Draw two cards.
• Target creature gets -5/-5 until end of turn.
{T}: Add {C}{C}. This mana can't be spent to cast nonartifact spells.
(Melds with Urza, Lord Protector.)

Boompile

{T}: Flip a coin. If you win the flip, destroy all nonland permanents.

Gush

You may return two Islands you control to their owner's hand rather than pay this spell's mana cost.
Draw two cards.

Laboratory Maniac

If you would draw a card while your library has no cards in it, you win the game instead.

Abstergo Entertainment

{T}: Add {C}.
{1}, {T}: Add one mana of any color.
{3}, {T}, Exile Abstergo Entertainment: Return up to one target historic card from your graveyard to your hand, then exile all graveyards. (Artifacts, legendaries, and Sagas are historic.)

Skrelv, Defector Mite

Toxic 1 (Players dealt combat damage by this creature also get a poison counter.)
Skrelv, Defector Mite can't block.
{W/P}, {T}: Choose a color. Another target creature you control gains toxic 1 and hexproof from that color until end of turn. It can't be blocked by creatures of that color this turn. ({W/P} can be paid with either {W} or 2 life.)

The Peregrine Dynamo

Haste
{1}, {T}: Copy target activated or triggered ability you control from another legendary source that's not a commander. You may choose new targets for the copy. (Mana abilities can't be targeted.)

Twinflame Tyrant

Flying
If a source you control would deal damage to an opponent or a permanent an opponent controls, it deals double that damage instead.

Stinging Study

You draw X cards and you lose X life, where X is the mana value of a commander you own on the battlefield or in the command zone.

Skysovereign, Consul Flagship

Flying
Whenever Skysovereign, Consul Flagship enters or attacks, it deals 3 damage to target creature or planeswalker an opponent controls.
Crew 3 (Tap any number of creatures you control with total power 3 or more: This Vehicle becomes an artifact creature until end of turn.)