Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Defiler of Flesh

Menace
As an additional cost to cast black permanent spells, you may pay 2 life. Those spells cost {B} less to cast if you paid life this way. This effect reduces only the amount of black mana you pay.
Whenever you cast a black permanent spell, target creature you control gets +1/+1 and gains menace until end of turn.

Blackblade Reforged

Equipped creature gets +1/+1 for each land you control.
Equip legendary creature {3}
Equip {7}

Lich's Mirror

If you would lose the game, instead shuffle your hand, your graveyard, and all permanents you own into your library, then draw seven cards and your life total becomes 20.

Duskfang Mentor

When Duskfang Mentor enters, put a lifelink counter on target non-Human creature you control.
{1}{B}, {T}: Put a +1/+1 counter on each creature you control with lifelink.

Murderous Betrayal

{B}{B}, Pay half your life, rounded up: Destroy target nonblack creature. It can't be regenerated.

Dark Ritual

Thrull Parasite

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
{T}, Pay 2 life: Remove a counter from target nonland permanent.

Wayfarer's Bauble

{2}, {T}, Sacrifice Wayfarer's Bauble: Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Font of Agonies

Whenever you pay life, put that many blood counters on Font of Agonies.
{1}{B}, Remove four blood counters from Font of Agonies: Destroy target creature.

Vampire Hexmage

First strike
Sacrifice Vampire Hexmage: Remove all counters from target permanent.

Worn Powerstone

Worn Powerstone enters tapped.
{T}: Add {C}{C}.

Whip of Erebos

Creatures you control have lifelink.
{2}{B}{B}, {T}: Return target creature card from your graveyard to the battlefield. It gains haste. Exile it at the beginning of the next end step. If it would leave the battlefield, exile it instead of putting it anywhere else. Activate only as a sorcery.

Agent of the Shadow Thieves

Commander creatures you own have "Whenever this creature attacks a player, if no opponent has more life than that player, put a +1/+1 counter on this creature. It gains deathtouch and indestructible until end of turn."

Dash Hopes

When you cast this spell, any player may pay 5 life. If a player does, counter Dash Hopes.
Counter target spell.

Mask of Griselbrand

Equipped creature has flying and lifelink.
Whenever equipped creature dies, you may pay X life, where X is its power. If you do, draw X cards.
Equip {3}

Pact Weapon

As long as Pact Weapon is attached to a creature, you don't lose the game for having 0 or less life.
Whenever equipped creature attacks, draw a card and reveal it. The creature gets +X/+X until end of turn and you lose X life, where X is that card's mana value.
Equip—Discard a card.

Basilisk Collar

Equipped creature has deathtouch and lifelink. (Any amount of damage it deals to a creature is enough to destroy it. Damage dealt by this creature also causes you to gain that much life.)
Equip {2} ({2}: Attach to target creature you control. Equip only as a sorcery.)

Grim Servant

Menace
When Grim Servant enters, search your library for a card with mana value less than or equal to your devotion to black, reveal it, put it into your hand, then shuffle. You lose 3 life. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Succumb to Temptation

Infernal Contract

Draw four cards. You lose half your life, rounded up.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

K'rrik, Son of Yawgmoth

({B/P} can be paid with either {B} or 2 life.)
Lifelink
For each {B} in a cost, you may pay 2 life rather than pay that mana.
Whenever you cast a black spell, put a +1/+1 counter on K'rrik, Son of Yawgmoth.

Soldevi Adnate

{T}, Sacrifice a black or artifact creature: Add an amount of {B} equal to the sacrificed creature's mana value.

Charcoal Diamond

Charcoal Diamond enters tapped.
{T}: Add {B}.

Diabolic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Devour in Shadow

Destroy target creature. It can't be regenerated. You lose life equal to that creature's toughness.

Mortarion, Daemon Primarch

Flying
Primarch of the Death Guard — At the beginning of your end step, you may pay {X}. If you do, create X 2/2 black Astartes Warrior creature tokens with menace. X can't be greater than the amount of life you lost this turn.

The Golden Throne

Arcane Life-support — If you would lose the game, instead exile The Golden Throne and your life total becomes 1.
A Thousand Souls Die Every Day — {T}, Sacrifice a creature: Add three mana in any combination of colors.

Loxodon Warhammer

Equipped creature gets +3/+0 and has trample and lifelink.
Equip {3}

Unspeakable Symbol

Pay 3 life: Put a +1/+1 counter on target creature.

Dark Favor

Enchant creature
When Dark Favor enters, you lose 1 life.
Enchanted creature gets +3/+1.

Triskaidekaphobia

At the beginning of your upkeep, choose one —
• Each player with exactly 13 life loses the game, then each player gains 1 life.
• Each player with exactly 13 life loses the game, then each player loses 1 life.

Death's Shadow

Death's Shadow gets -X/-X, where X is your life total.

Underworld Connections

Enchant land
Enchanted land has "{T}, Pay 1 life: Draw a card."

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Wall of Blood

Defender (This creature can't attack.)
Pay 1 life: Wall of Blood gets +1/+1 until end of turn.

Rogue's Passage

{T}: Add {C}.
{4}, {T}: Target creature can't be blocked this turn.

Fain, the Broker

{T}, Sacrifice a creature: Put two +1/+1 counters on target creature.
{T}, Remove a counter from a creature you control: Create a Treasure token.
{T}, Sacrifice an artifact: Create a 2/1 white and black Inkling creature token with flying.
{3}{B}: Untap Fain, the Broker.

Platinum Angel

Flying
You can't lose the game and your opponents can't win the game.

Phyresis

Enchant creature
Enchanted creature has infect. (It deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)

Soul Channeling

Enchant creature
Pay 2 life: Regenerate enchanted creature.

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Hexavus

Flying
Hexavus enters with six +1/+1 counters on it.
{1}, Remove a +1/+1 counter from Hexavus: Put a flying counter on another target creature.
{1}, Remove a counter from another creature you control: Put a +1/+1 counter on Hexavus.

Gallowbraid

Trample
Cumulative upkeep—Pay 1 life. (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)

Shadow of Mortality

If your life total is less than your starting life total, this spell costs {X} less to cast, where X is the difference.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Marshland Bloodcaster

Flying
{1}{B}, {T}: Rather than pay the mana cost of the next spell you cast this turn, you may pay life equal to that spell's mana value.

Swamp

Magus of the Mirror

{T}, Sacrifice Magus of the Mirror: Exchange life totals with target opponent. Activate only during your upkeep.

Barren Moor

Barren Moor enters tapped.
{T}: Add {B}.
Cycling {B} ({B}, Discard this card: Draw a card.)

Mortuary Mire

Mortuary Mire enters tapped.
When Mortuary Mire enters, you may put target creature card from your graveyard on top of your library.
{T}: Add {B}.

Beseech the Queen

({2/B} can be paid with any two mana or with {B}. This card's mana value is 6.)
Search your library for a card with mana value less than or equal to the number of lands you control, reveal it, put it into your hand, then shuffle.

Greed

Leaden Myr

Lich's Mastery

Hexproof
You can't lose the game.
Whenever you gain life, draw that many cards.
Whenever you lose life, for each 1 life you lost, exile a permanent you control or a card from your hand or graveyard.
When Lich's Mastery leaves the battlefield, you lose the game.

Morinfen

Flying
Cumulative upkeep—Pay 1 life. (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)

Blood Celebrant

{B}, Pay 1 life: Add one mana of any color.

Infernal Grasp

Destroy target creature. You lose 2 life.

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Soul Conduit

{6}, {T}: Two target players exchange life totals.

Lich's Tomb

You don't lose the game for having 0 or less life.
Whenever you lose life, sacrifice a permanent for each 1 life you lost. (Damage causes loss of life.)

Hand of Vecna

At the beginning of combat on your turn, equipped creature or a creature you control named Vecna gets +X/+X until end of turn, where X is the number of cards in your hand.
Equip—Pay 1 life for each card in your hand.
Equip {2}

Sign in Blood

Target player draws two cards and loses 2 life.

Withering Boon

As an additional cost to cast this spell, pay 3 life.
Counter target creature spell.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Torgaar, Famine Incarnate

As an additional cost to cast this spell, you may sacrifice any number of creatures. This spell costs {2} less to cast for each creature sacrificed this way.
When Torgaar, Famine Incarnate enters, up to one target player's life total becomes half their starting life total, rounded down.