Laboratory Maniac

If you would draw a card while your library has no cards in it, you win the game instead.

Barrowgoyf

Deathtouch, lifelink
Barrowgoyf's power is equal to the number of card types among cards in all graveyards and its toughness is equal to that number plus 1.
Whenever Barrowgoyf deals combat damage to a player, you may mill that many cards. If you do, you may put a creature card from among them into your hand.

Enduring Tenacity

Whenever you gain life, target opponent loses that much life.
When Enduring Tenacity dies, if it was a creature, return it to the battlefield under its owner's control. It's an enchantment. (It's not a creature.)

Altar of Dementia

Sacrifice a creature: Target player mills cards equal to the sacrificed creature's power.

Bontu the Glorified

Menace, indestructible
Bontu the Glorified can't attack or block unless a creature died under your control this turn.
{1}{B}, Sacrifice another creature: Scry 1. Each opponent loses 1 life and you gain 1 life.

Vraska, Golgari Queen

+2: You may sacrifice another permanent. If you do, you gain 1 life and draw a card.
−3: Destroy target nonland permanent with mana value 3 or less.
−9: You get an emblem with "Whenever a creature you control deals combat damage to a player, that player loses the game."

Negate

Rhonas the Indomitable

Deathtouch, indestructible
Rhonas the Indomitable can't attack or block unless you control another creature with power 4 or greater.
{2}{G}: Another target creature gets +2/+0 and gains trample until end of turn.

Daring Fiendbonder

Haste
Daring Fiendbonder attacks each combat if able.
{1}{B}, Exile Daring Fiendbonder from your graveyard: Put an indestructible counter on target creature. Activate only as a sorcery.

Darksteel Ingot

Indestructible (Effects that say "destroy" don't destroy this artifact.)
{T}: Add one mana of any color.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Swamp

Jace's Erasure

Whenever you draw a card, you may have target player mill a card.

Creeping Bloodsucker

At the beginning of your upkeep, Creeping Bloodsucker deals 1 damage to each opponent. You gain life equal to the damage dealt this way.

Crawling Infestation

At the beginning of your upkeep, you may mill two cards. (You may put the top two cards of your library into your graveyard.)
Whenever one or more creature cards are put into your graveyard from anywhere during your turn, create a 1/1 green Insect creature token. This ability triggers only once each turn.

Bighorner Rancher

Vigilance
{T}: Add an amount of {G} equal to the greatest power among creatures you control.
Sacrifice Bighorner Rancher: You gain life equal to the greatest toughness among other creatures you control.

Lich's Mastery

Hexproof
You can't lose the game.
Whenever you gain life, draw that many cards.
Whenever you lose life, for each 1 life you lost, exile a permanent you control or a card from your hand or graveyard.
When Lich's Mastery leaves the battlefield, you lose the game.

Ashnod's Altar

Spore Frog

Sacrifice Spore Frog: Prevent all combat damage that would be dealt this turn.

Marina Vendrell's Grimoire

When Marina Vendrell's Grimoire enters, if you cast it, draw five cards.
You have no maximum hand size and don't lose the game for having 0 or less life.
Whenever you gain life, draw that many cards.
Whenever you lose life, discard that many cards. Then if you have no cards in hand, you lose the game.

Leeching Lurker

Lifelink
Nightbound (If a player casts at least two spells during their own turn, it becomes day next turn.)

Curse of Leeches

Enchant player
As this permanent transforms into Curse of Leeches, attach it to a player.
At the beginning of enchanted player's upkeep, they lose 1 life and you gain 1 life.
Daybound (If a player casts no spells during their own turn, it becomes night next turn.)

Curse of Leeches // Leeching Lurker

Blight Titan

Deathtouch
Whenever Blight Titan enters or attacks, mill two cards, then incubate X, where X is the number of creature cards in your graveyard. (Create an Incubator token with X +1/+1 counters on it and "{2}: Transform this artifact." It transforms into a 0/0 Phyrexian artifact creature.)

Polluted Bonds

Whenever a land an opponent controls enters, that player loses 2 life and you gain 2 life.

Cephalid Vandal

At the beginning of your upkeep, put a shred counter on Cephalid Vandal. Then mill a card for each shred counter on Cephalid Vandal.

Bottle Gnomes

Sacrifice Bottle Gnomes: You gain 3 life.

Titania's Command

Choose two —
• Exile target player's graveyard. You gain 1 life for each card exiled this way.
• Search your library for up to two land cards, put them onto the battlefield tapped, then shuffle.
• Create two 2/2 green Bear creature tokens.
• Put two +1/+1 counters on each creature you control.

Kefnet the Mindful

Flying, indestructible
Kefnet the Mindful can't attack or block unless you have seven or more cards in hand.
{3}{U}: Draw a card, then you may return a land you control to its owner's hand.

Glowing One

Deathtouch
Whenever Glowing One deals combat damage to a player, they get four rad counters.
Whenever a player mills a nonland card, you gain 1 life.

Nefarious Lich

If damage would be dealt to you, exile that many cards from your graveyard instead. If you can't, you lose the game.
If you would gain life, draw that many cards instead.
When Nefarious Lich leaves the battlefield, you lose the game.

Ripples of Undeath

At the beginning of your first main phase, mill three cards. Then you may pay {1} and 3 life. If you do, put a card from among those cards into your hand.

Toski, Bearer of Secrets

This spell can't be countered.
Indestructible
Toski, Bearer of Secrets attacks each combat if able.
Whenever a creature you control deals combat damage to a player, draw a card.

Krosan Grip

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
Destroy target artifact or enchantment.

Bristlebud Farmer

Trample
When Bristlebud Farmer enters, create two Food tokens. (They're artifacts with "{2}, {T}, Sacrifice this artifact: You gain 3 life.")
Whenever Bristlebud Farmer attacks, you may sacrifice a Food. If you do, mill three cards. You may put a permanent card from among them into your hand.

Jace, Wielder of Mysteries

If you would draw a card while your library has no cards in it, you win the game instead.
+1: Target player mills two cards. Draw a card.
−8: Draw seven cards. Then if your library has no cards in it, you win the game.

Beledros Witherbloom

Flying
At the beginning of each upkeep, create a 1/1 black and green Pest creature token with "When this creature dies, you gain 1 life."
Pay 10 life: Untap all lands you control. Activate only once each turn.

Growth Spiral

Draw a card. You may put a land card from your hand onto the battlefield.

Kodama's Reach

Search your library for up to two basic land cards, reveal those cards, put one onto the battlefield tapped and the other into your hand, then shuffle.

Psychic Corrosion

Whenever you draw a card, each opponent mills two cards.

Insidious Mist

Hexproof, indestructible
Insidious Mist can't block and can't be blocked.
Whenever Insidious Mist attacks and isn't blocked, you may pay {2}{B}. If you do, transform it.

Elusive Tormentor

{1}, Discard a card: Transform Elusive Tormentor.

Elusive Tormentor // Insidious Mist

Soulflayer

Delve (Each card you exile from your graveyard while casting this spell pays for {1}.)
If a creature card with flying was exiled with Soulflayer's delve ability, Soulflayer has flying. The same is true for first strike, double strike, deathtouch, haste, hexproof, indestructible, lifelink, reach, trample, and vigilance.

Myojin of Grim Betrayal

Myojin of Grim Betrayal enters with an indestructible counter on it if you cast it from your hand.
Remove an indestructible counter from Myojin of Grim Betrayal: Put onto the battlefield under your control all creature cards in all graveyards that were put there from anywhere this turn.

Counterspell

An Offer You Can't Refuse

Counter target noncreature spell. Its controller creates two Treasure tokens. (They're artifacts with "{T}, Sacrifice this token: Add one mana of any color.")

Beseech the Mirror

Bargain (You may sacrifice an artifact, enchantment, or token as you cast this spell.)
Search your library for a card, exile it face down, then shuffle. If this spell was bargained, you may cast the exiled card without paying its mana cost if that spell's mana value is 4 or less. Put the exiled card into your hand if it wasn't cast this way.

Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on Bloodchief Ascension. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if Bloodchief Ascension has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Heroic Intervention

Permanents you control gain hexproof and indestructible until end of turn.

Disciple of Griselbrand

{1}, Sacrifice a creature: You gain life equal to the sacrificed creature's toughness.

Enduring Curiosity

Flash
Whenever a creature you control deals combat damage to a player, draw a card.
When Enduring Curiosity dies, if it was a creature, return it to the battlefield under its owner's control. It's an enchantment. (It's not a creature.)

Skyclave Relic

Kicker {3}
Indestructible
When Skyclave Relic enters, if it was kicked, create two tapped tokens that are copies of Skyclave Relic.
{T}: Add one mana of any color.

Haywire Mite

When Haywire Mite dies, you gain 2 life.
{G}, Sacrifice Haywire Mite: Exile target noncreature artifact or noncreature enchantment.

Soul of New Phyrexia

Trample
{5}: Permanents you control gain indestructible until end of turn.
{5}, Exile Soul of New Phyrexia from your graveyard: Permanents you control gain indestructible until end of turn.

Bramble Wurm

Reach, trample
When Bramble Wurm enters, you gain 5 life.
{2}{G}, Exile Bramble Wurm from your graveyard: You gain 5 life.

Crawling Sensation

At the beginning of your upkeep, you may mill two cards. (You may put the top two cards of your library into your graveyard.)
Whenever one or more land cards are put into your graveyard from anywhere for the first time each turn, create a 1/1 green Insect creature token.

Life's Finale

Destroy all creatures, then search target opponent's library for up to three creature cards and put them into their graveyard. Then that player shuffles.

Brindle Boar

Thassa, God of the Sea

Indestructible
As long as your devotion to blue is less than five, Thassa isn't a creature. (Each {U} in the mana costs of permanents you control counts toward your devotion to blue.)
At the beginning of your upkeep, scry 1.
{1}{U}: Target creature you control can't be blocked this turn.

Rampant Growth

Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Vampiric Tutor

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Sol Ring

Diabolic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Muldrotha, the Gravetide

During each of your turns, you may play a land and cast a permanent spell of each permanent type from your graveyard. (If a card has multiple permanent types, choose one as you play it.)

Underrealm Lich

If you would draw a card, instead look at the top three cards of your library, then put one into your hand and the rest into your graveyard.
Pay 4 life: Underrealm Lich gains indestructible until end of turn. Tap it.

Lich

As Lich enters, you lose life equal to your life total.
You don't lose the game for having 0 or less life.
If you would gain life, draw that many cards instead.
Whenever you're dealt damage, sacrifice that many nontoken permanents. If you can't, you lose the game.
When Lich is put into a graveyard from the battlefield, you lose the game.

Reality Shift

Exile target creature. Its controller manifests the top card of their library. (That player puts the top card of their library onto the battlefield face down as a 2/2 creature. If it's a creature card, it can be turned face up any time for its mana cost.)

The Ancient One

Descend 8 — The Ancient One can't attack or block unless there are eight or more permanent cards in your graveyard.
{2}{U}{B}: Draw a card, then discard a card. When you discard a card this way, target player mills cards equal to its mana value.

Aftermath Analyst

When Aftermath Analyst enters, mill three cards.
{3}{G}, Sacrifice Aftermath Analyst: Return all land cards from your graveyard to the battlefield tapped.

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Darkheart Sliver

All Slivers have "Sacrifice this permanent: You gain 3 life."

Enduring Vitality

Vigilance
Creatures you control have "{T}: Add one mana of any color."
When Enduring Vitality dies, if it was a creature, return it to the battlefield under its owner's control. It's an enchantment. (It's not a creature.)

Lich-Knights' Conquest

Sacrifice any number of artifacts, enchantments, and/or tokens. Return that many creature cards from your graveyard to the battlefield.

Island

Vashta Nerada

Indestructible
Shadow (This creature can block or be blocked by only creatures with shadow.)
Morbid — At the beginning of each end step, if a creature died this turn, put a +1/+1 counter on Vashta Nerada.

Farseek

Search your library for a Plains, Island, Swamp, or Mountain card, put it onto the battlefield tapped, then shuffle.

Phylactery Lich

Indestructible
As Phylactery Lich enters, put a phylactery counter on an artifact you control.
When you control no permanents with phylactery counters on them, sacrifice Phylactery Lich.

Demonic Tutor

Cultivate

Forest

Courser of Kruphix

Play with the top card of your library revealed.
You may play lands from the top of your library.
Landfall — Whenever a land you control enters, you gain 1 life.