Possible cut

Ayara, First of Locthwain

Whenever Ayara or another black creature you control enters, each opponent loses 1 life and you gain 1 life.
{T}, Sacrifice another black creature: Draw a card.

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Sign in Blood

Target player draws two cards and loses 2 life.

Considering

Blasphemous Edict

You may pay {B} rather than pay this spell's mana cost if there are thirteen or more creatures on the battlefield.
Each player sacrifices thirteen creatures of their choice.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Someday

Shadowspear

Equipped creature gets +1/+1 and has trample and lifelink.
{1}: Permanents your opponents control lose hexproof and indestructible until end of turn.
Equip {2}

Enduring Tenacity

Whenever you gain life, target opponent loses that much life.
When Enduring Tenacity dies, if it was a creature, return it to the battlefield under its owner's control. It's an enchantment. (It's not a creature.)

Nashi, Moon Sage's Scion

Ninjutsu {3}{B} ({3}{B}, Return an unblocked attacker you control to hand: Put this card onto the battlefield from your hand tapped and attacking.)
Whenever Nashi deals combat damage to a player, exile the top card of each player's library. Until end of turn, you may play one of those cards. If you cast a spell this way, pay life equal to its mana value rather than paying its mana cost.

Kaya's Ghostform

Enchant creature or planeswalker you control
When enchanted permanent dies or is put into exile, return that card to the battlefield under your control.

Midnight Snack

Raid — At the beginning of your end step, if you attacked this turn, create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this token: You gain 3 life.")
{2}{B}, Sacrifice this enchantment: Target opponent loses X life, where X is the amount of life you gained this turn.

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice this artifact: Draw a card.

Malakir Mire

Malakir Rebirth

Choose target creature. You lose 2 life. Until end of turn, that creature gains "When this creature dies, return it to the battlefield tapped under its owner's control."

Malakir Rebirth // Malakir Mire

Liliana, Dreadhorde General

Whenever a creature you control dies, draw a card.
+1: Create a 2/2 black Zombie creature token.
−4: Each player sacrifices two creatures of their choice.
−9: Each opponent chooses a permanent they control of each permanent type and sacrifices the rest.

Bontu's Monument

Black creature spells you cast cost {1} less to cast.
Whenever you cast a creature spell, each opponent loses 1 life and you gain 1 life.

Make an Example

Each opponent separates the creatures they control into two piles. For each opponent, you choose one of their piles. Each opponent sacrifices the creatures in their chosen pile. (Piles can be empty.)

Fell Mire

As this land enters, you may pay 3 life. If you don't, it enters tapped.
{T}: Add {B}.

Fell the Profane

Fell the Profane // Fell Mire

Ogre Slumlord

Whenever another nontoken creature dies, you may create a 1/1 black Rat creature token.
Rats you control have deathtouch.

Vampiric Link

Enchant creature
Whenever enchanted creature deals damage, you gain that much life.

Font of Agonies

Whenever you pay life, put that many blood counters on this enchantment.
{1}{B}, Remove four blood counters from this enchantment: Destroy target creature.

Sword of Light and Shadow

Equipped creature gets +2/+2 and has protection from white and from black.
Whenever equipped creature deals combat damage to a player, you gain 3 life and you may return up to one target creature card from your graveyard to your hand.
Equip {2}

Dark Ritual

Defile

Target creature gets -1/-1 until end of turn for each Swamp you control.

One Ring to Rule Them All

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — The Ring tempts you, then each player mills cards equal to your Ring-bearer's power.
II — Destroy all nonlegendary creatures.
III — Each opponent loses 1 life for each creature card in that player's graveyard.

Lightning Greaves

Equipped creature has haste and shroud. (It can't be the target of spells or abilities.)
Equip {0}

Sangromancer

Flying
Whenever a creature an opponent controls dies, you may gain 3 life.
Whenever an opponent discards a card, you may gain 3 life.

Rankle, Master of Pranks

Flying, haste
Whenever Rankle deals combat damage to a player, choose any number —
• Each player discards a card.
• Each player loses 1 life and draws a card.
• Each player sacrifices a creature of their choice.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Gifted Aetherborn

Witch of the Moors

Deathtouch
At the beginning of your end step, if you gained life this turn, each opponent sacrifices a creature of their choice and you return up to one target creature card from your graveyard to your hand.

Boggart Bog

Boggart Trawler

When this creature enters, exile target player's graveyard.

Boggart Trawler // Boggart Bog

Charcoal Diamond

This artifact enters tapped.
{T}: Add {B}.

Sol Ring

Reckoner's Bargain

As an additional cost to cast this spell, sacrifice an artifact or creature.
You gain life equal to the sacrificed permanent's mana value. Draw two cards.

Brotherhood Regalia

Equipped creature has ward {2}, is an Assassin in addition to its other types, and can't be blocked.
Equip legendary creature {1}
Equip {3} ({3}: Attach to target creature you control. Equip only as a sorcery.)

Strionic Resonator

{2}, {T}: Copy target triggered ability you control. You may choose new targets for the copy. (A triggered ability uses the words "when," "whenever," or "at.")

Whip of Erebos

Creatures you control have lifelink.
{2}{B}{B}, {T}: Return target creature card from your graveyard to the battlefield. It gains haste. Exile it at the beginning of the next end step. If it would leave the battlefield, exile it instead of putting it anywhere else. Activate only as a sorcery.

Dauthi Embrace

{B}{B}: Target creature gains shadow until end of turn. (It can block or be blocked by only creatures with shadow.)

Temple of Aclazotz

(Transforms from Arguel's Blood Fast.)
{T}: Add {B}.
{T}, Sacrifice a creature: You gain life equal to the sacrificed creature's toughness.

Arguel's Blood Fast

{1}{B}, Pay 2 life: Draw a card.
At the beginning of your upkeep, if you have 5 or less life, you may transform Arguel's Blood Fast.

Arguel's Blood Fast // Temple of Aclazotz

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Ink-Eyes, Servant of Oni

Ninjutsu {3}{B}{B} ({3}{B}{B}, Return an unblocked attacker you control to hand: Put this card onto the battlefield from your hand tapped and attacking.)
Whenever Ink-Eyes deals combat damage to a player, you may put target creature card from that player's graveyard onto the battlefield under your control.
{1}{B}: Regenerate Ink-Eyes.

Access Tunnel

{T}: Add {C}.
{3}, {T}: Target creature with power 3 or less can't be blocked this turn.

Phyrexian Tower

{T}: Add {C}.
{T}, Sacrifice a creature: Add {B}{B}.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control. It can attack and {T} no matter when it came under your control.)
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)

Bojuka Bog

This land enters tapped.
When this land enters, exile target player's graveyard.
{T}: Add {B}.

Scheming Symmetry

Choose two target players. Each of them searches their library for a card, then shuffles and puts that card on top.

Lavaspur Boots

Equipped creature gets +1/+0 and has haste and ward {1}. (Whenever it becomes the target of a spell or ability an opponent controls, counter it unless that player pays {1}.)
Equip {1}

Call of the Ring

At the beginning of your upkeep, the Ring tempts you.
Whenever you choose a creature as your Ring-bearer, you may pay 2 life. If you do, draw a card.

Baleful Mastery

You may pay {1}{B} rather than pay this spell's mana cost.
If the {1}{B} cost was paid, an opponent draws a card.
Exile target creature or planeswalker.

Soul Shatter

Each opponent sacrifices a creature or planeswalker with the greatest mana value among creatures and planeswalkers they control.

The Black Gate

As The Black Gate enters, you may pay 3 life. If you don't, it enters tapped.
{T}: Add {B}.
{1}{B}, {T}: Choose a player with the most life or tied for most life. Target creature can't be blocked by creatures that player controls this turn.

Bitter Triumph

As an additional cost to cast this spell, discard a card or pay 3 life.
Destroy target creature or planeswalker.

Gollum, Obsessed Stalker

Skulk (This creature can't be blocked by creatures with greater power.)
At the beginning of your end step, each opponent dealt combat damage this game by a creature named Gollum, Obsessed Stalker loses life equal to the amount of life you gained this turn.

Minas Morgul, Dark Fortress

Minas Morgul enters tapped.
{T}: Add {B}.
{3}{B}, {T}: Put a shadow counter on target creature. For as long as that creature has a shadow counter on it, it's a Wraith in addition to its other types. (A creature with shadow can block or be blocked by only creatures with shadow.)

War Room

{T}: Add {C}.
{3}, {T}, Pay life equal to the number of colors in your commanders' color identity: Draw a card.

Ancient Cellarspawn

Each spell you cast that's a Demon, Horror, or Nightmare costs {1} less to cast.
Whenever you cast a spell, if the amount of mana spent to cast it was less than its mana value, target opponent loses life equal to the difference.

Sword of Feast and Famine

Equipped creature gets +2/+2 and has protection from black and from green.
Whenever equipped creature deals combat damage to a player, that player discards a card and you untap all lands you control.
Equip {2}

Vampire Nighthawk

Flying
Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)

Command Beacon

{T}: Add {C}.
{T}, Sacrifice this land: Put your commander into your hand from the command zone.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Black Market Connections

At the beginning of your first main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It is every creature type.)

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Witch-king of Angmar

Flying
Whenever one or more creatures deal combat damage to you, each opponent sacrifices a creature of their choice that dealt combat damage to you this turn. The Ring tempts you.
Discard a card: Witch-king of Angmar gains indestructible until end of turn. Tap it.

Netherborn Altar

{T}, Put a soul counter on this artifact: Put your commander into your hand from the command zone. Then you lose 3 life for each soul counter on this artifact.

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Basilisk Collar

Equipped creature has deathtouch and lifelink. (Any amount of damage it deals to a creature is enough to destroy it. Damage dealt by this creature also causes you to gain that much life.)
Equip {2} ({2}: Attach to target creature you control. Equip only as a sorcery.)

Basilica Screecher

Flying
Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)

Piper of the Swarm

Rats you control have menace.
{1}{B}, {T}: Create a 1/1 black Rat creature token.
{2}{B}{B}, {T}, Sacrifice three Rats: Gain control of target creature.

Throne of Eldraine

As Throne of Eldraine enters, choose a color.
{T}: Add four mana of the chosen color. Spend this mana only to cast monocolored spells of that color.
{3}, {T}: Draw two cards. Spend only mana of the chosen color to activate this ability.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Grim Hireling

Whenever one or more creatures you control deal combat damage to a player, create two Treasure tokens.
{B}, Sacrifice X Treasures: Target creature gets -X/-X until end of turn. Activate only as a sorcery.

Disciple of Bolas

When this creature enters, sacrifice another creature. You gain X life and draw X cards, where X is that creature's power.

Mask of Griselbrand

Equipped creature has flying and lifelink.
Whenever equipped creature dies, you may pay X life, where X is its power. If you do, draw X cards.
Equip {3}

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Nighthawk Scavenger

Flying, deathtouch, lifelink
Nighthawk Scavenger's power is equal to 1 plus the number of card types among cards in your opponents' graveyards.

Wurmcoil Engine

Deathtouch, lifelink
When this creature dies, create a 3/3 colorless Phyrexian Wurm artifact creature token with deathtouch and a 3/3 colorless Phyrexian Wurm artifact creature token with lifelink.

Cabal Coffers

{2}, {T}: Add {B} for each Swamp you control.

Shizo, Death's Storehouse

{T}: Add {B}.
{B}, {T}: Target legendary creature gains fear until end of turn. (It can't be blocked except by artifact creatures and/or black creatures.)

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Qarsi Revenant

Flying, deathtouch, lifelink
Renew — {2}{B}, Exile this card from your graveyard: Put a flying counter, a deathtouch counter, and a lifelink counter on target creature. Activate only as a sorcery.

Portal to Phyrexia

When this artifact enters, each opponent sacrifices three creatures of their choice.
At the beginning of your upkeep, put target creature card from a graveyard onto the battlefield under your control. It's a Phyrexian in addition to its other types.

Rogue's Passage

{T}: Add {C}.
{4}, {T}: Target creature can't be blocked this turn.

Protection Racket

At the beginning of your upkeep, repeat the following process for each opponent in turn order. Reveal the top card of your library. That player may pay life equal to that card's mana value. If they do, exile that card. Otherwise, put it into your hand.

Cliffhaven Kitesail

When this Equipment enters, attach it to target creature you control.
Equipped creature has flying.
Equip {2} ({2}: Attach to target creature you control. Equip only as a sorcery.)

Witch's Clinic

{T}: Add {C}.
{2}, {T}: Target commander gains lifelink until end of turn.

Night's Whisper

Black Market

Whenever a creature dies, put a charge counter on this enchantment.
At the beginning of your first main phase, add {B} for each charge counter on this enchantment.

Virtus the Veiled

Partner with Gorm the Great (When this creature enters, target player may put Gorm into their hand from their library, then shuffle.)
Deathtouch
Whenever Virtus deals combat damage to a player, that player loses half their life, rounded up.

Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on this enchantment. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if this enchantment has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Swarmyard

{T}: Add {C}.
{T}: Regenerate target Insect, Rat, Spider, or Squirrel. (The next time it would be destroyed this turn, instead tap it, remove it from combat, and heal all damage on it.)

Defiler of Flesh

Menace
As an additional cost to cast black permanent spells, you may pay 2 life. Those spells cost {B} less to cast if you paid life this way. This effect reduces only the amount of black mana you pay.
Whenever you cast a black permanent spell, target creature you control gets +1/+1 and gains menace until end of turn.

Sensei's Divining Top

{1}: Look at the top three cards of your library, then put them back in any order.
{T}: Draw a card, then put this artifact on top of its owner's library.

Rush of Dread

Spree (Choose one or more additional costs.)
+ {1} — Target opponent sacrifices half the creatures they control of their choice, rounded up.
+ {2} — Target opponent discards half the cards in their hand, rounded up.
+ {2} — Target opponent loses half their life, rounded up.

Twilight Prophet

Flying
Ascend (If you control ten or more permanents, you get the city's blessing for the rest of the game.)
At the beginning of your upkeep, if you have the city's blessing, reveal the top card of your library and put it into your hand. Each opponent loses X life and you gain X life, where X is that card's mana value.

Scavenged Brawler

Flying, vigilance, trample, lifelink
{5}, Exile this card from your graveyard: Choose target creature. Put four +1/+1 counters, a flying counter, a vigilance counter, a trample counter, and a lifelink counter on that creature. Activate only as a sorcery.

Shard of the Nightbringer

Flying
Drain Life — When this creature enters, if you cast it, target opponent loses half their life, rounded up. You gain life equal to the life lost this way.

Mithril Coat

Flash
Indestructible
When Mithril Coat enters, attach it to target legendary creature you control.
Equipped creature has indestructible.
Equip {3}

Kokusho, the Evening Star

Flying
When Kokusho dies, each opponent loses 5 life. You gain life equal to the life lost this way.