Ad Nauseam

Reveal the top card of your library and put that card into your hand. You lose life equal to its mana value. You may repeat this process any number of times.

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Castle Locthwain

Castle Locthwain enters tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Opposition Agent

Flash
You control your opponents while they're searching their libraries.
While an opponent is searching their library, they exile each card they find. You may play those cards for as long as they remain exiled, and you may spend mana as though it were mana of any color to cast them.

Devour in Shadow

Destroy target creature. It can't be regenerated. You lose life equal to that creature's toughness.

The One Ring

Indestructible
When The One Ring enters, if you cast it, you gain protection from everything until your next turn.
At the beginning of your upkeep, you lose 1 life for each burden counter on The One Ring.
{T}: Put a burden counter on The One Ring, then draw a card for each burden counter on The One Ring.

The Reaver Cleaver

Equipped creature gets +1/+1 and has trample and "Whenever this creature deals combat damage to a player or planeswalker, create that many Treasure tokens."
Equip {3}

Auntie Blyte, Bad Influence

Flying
Whenever a source you control deals damage to you, put that many +1/+1 counters on Auntie Blyte, Bad Influence.
{1}{R}, {T}, Remove X +1/+1 counters from Auntie Blyte: It deals X damage to any target.

Simian Spirit Guide

Exile Simian Spirit Guide from your hand: Add {R}.

Volcano Hellion

Volcano Hellion has echo {X}, where X is your life total. (At the beginning of your upkeep, if this came under your control since the beginning of your last upkeep, sacrifice it unless you pay its echo cost.)
When Volcano Hellion enters, it deals an amount of damage of your choice to you and target creature. The damage can't be prevented.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Greven, Predator Captain

Menace
Greven, Predator Captain gets +X/+0, where X is the amount of life you've lost this turn.
Whenever Greven attacks, you may sacrifice another creature. If you do, you draw cards equal to that creature's power and you lose life equal to that creature's toughness.

Defiler of Instinct

First strike
As an additional cost to cast red permanent spells, you may pay 2 life. Those spells cost {R} less to cast if you paid life this way. This effect reduces only the amount of red mana you pay.
Whenever you cast a red permanent spell, Defiler of Instinct deals 1 damage to any target.

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